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Anatomical distance affects functional connectivity at rest in medicine-free obsessive-compulsive disorder

文献类型：期刊论文

作者Lv, Dan8; Ou, Yangpan6,7; Chen, Yunhui8; Ding, Zhenning8; Ma, Jidong5; Zhan, Chuang5; Yang, Ru4; Shang, Tinghuizi8; Zhang, Guangfeng3; Bai, Xiaoyu1,2
刊名BMC PSYCHIATRY
出版日期2022-10-12
卷号22期号:1页码:10
关键词obsessive-compulsive disorder Anatomical distance Short-range Long-range Functional connectivity
DOI10.1186/s12888-022-04103-x
通讯作者Guo, Wenbin(guowenbin76@csu.edu.cn) ; Li, Ping(lipingchxyy@163.com)
英文摘要Background Brain functional abnormalities at rest have been observed in obsessive-compulsive disorder (OCD). However, whether and how anatomical distance influences functional connectivity (FC) at rest is ambiguous in OCD. Methods Using resting-state functional magnetic resonance imaging data, we calculated the FC of each voxel in the whole-brain and divided FC into short- and long-range FCs in 40 medicine-free patients with OCD and 40 healthy controls (HCs). A support vector machine (SVM) was used to determine whether the altered short- and long-range FCs could be utilized to distinguish OCD from HCs. Results Patients had lower short-range positive FC (spFC) and long-range positive FC (lpFC) in the left precentral/postcentral gyrus (t = -5.57 and -5.43; P < 0.05, GRF corrected) and higher lpFC in the right thalamus/caudate, left thalamus, left inferior parietal lobule (IPL) and left cerebellum CrusI/VI (t = 4.59, 4.61, 4.41, and 5.93; P < 0.05, GRF corrected). Furthermore, lower spFC in the left precentral/postcentral gyrus might be used to distinguish OCD from HCs with an accuracy of 80.77%, a specificity of 81.58%, and a sensitivity of 80.00%. Conclusion These findings highlight that anatomical distance has an effect on the whole-brain FC patterns at rest in OCD. Meanwhile, lower spFC in the left precentral/postcentral gyrus might be applied in distinguishing OCD from HCs.
收录类别SCI
WOS关键词SHORT-RANGE ; NAIVE SCHIZOPHRENIA ; 1ST-EPISODE ; NETWORKS ; CORTEX
资助项目Qiqihar Academy of Medical Sciences Project[QMSI2021M-07] ; Natural Science Foundation of Heilongjiang Province, China[LH2019H064]
WOS研究方向Psychiatry
语种英语
出版者BMC
WOS记录号WOS:000866109500001
资助机构Qiqihar Academy of Medical Sciences Project ; Natural Science Foundation of Heilongjiang Province, China
源URL[http://ir.psych.ac.cn/handle/311026/43513]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Guo, Wenbin; Li, Ping
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
2.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
3.Qiqihar Med Univ, Dept Radiol, Affiliated Hosp 3, Qiqihar, Peoples R China
4.Cent South Univ, Dept Radiol, Xiangya Hosp 2, Changsha, Peoples R China
5.Baiyupao Psychiat Hosp Harbin, Dept Psychiat, Harbin, Peoples R China
6.Cent South Univ, Natl Clin Res Ctr Mental Disorders, Xiangya Hosp 2, Changsha, Peoples R China
7.Cent South Univ, Dept Psychiat, Xiangya Hosp 2, Changsha, Peoples R China
8.Qiqihar Med Univ, Dept Psychiat, Qiqihar, Peoples R China
推荐引用方式
GB/T 7714		 Lv, Dan,Ou, Yangpan,Chen, Yunhui,et al. Anatomical distance affects functional connectivity at rest in medicine-free obsessive-compulsive disorder[J]. BMC PSYCHIATRY,2022,22(1):10.
APA Lv, Dan.,Ou, Yangpan.,Chen, Yunhui.,Ding, Zhenning.,Ma, Jidong.,...&Li, Ping.(2022).Anatomical distance affects functional connectivity at rest in medicine-free obsessive-compulsive disorder.BMC PSYCHIATRY,22(1),10.
MLA Lv, Dan,et al."Anatomical distance affects functional connectivity at rest in medicine-free obsessive-compulsive disorder".BMC PSYCHIATRY 22.1(2022):10.

入库方式： OAI收割

来源：心理研究所

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