The diagnostic value of the olfactory evaluation for congenital hypogonadotropic hypogonadism
文献类型:期刊论文
作者 | Yu, Bingqing5; Chen, Kepu2,3,4; Mao, Jiangfeng5; Hou, Bo1; You, Hui1; Wang, Xi5; Nie, Min5; Huang, Qibin5; Zhang, Rui5; Zhu, Yiyi5 |
刊名 | FRONTIERS IN ENDOCRINOLOGY |
出版日期 | 2022-09-16 |
卷号 | 13页码:10 |
ISSN号 | 1664-2392 |
关键词 | hypogonadotropic hypogonadism Kallmann syndrome Chinese olfactory function test MRI olfactory bulb |
DOI | 10.3389/fendo.2022.909623 |
通讯作者 | Wu, Xueyan(wsheyan@vip.sina.com) |
英文摘要 | ObjectiveThe aim of this study was to evaluate the diagnostic accuracy of different olfactory evaluation tools in congenital hypogonadotropic hypogonadism (CHH) patients. MethodsSeventy-one CHH patients were prospectively recruited at Peking Union Medical College Hospital between November 2020 and July 2021. The Chinese Olfactory Function Test (COFT) and Self-reported Olfactory Scale (SROS) were adapted as the subjective tools for the evaluation of olfactory function, and magnetic resonance imaging of olfactory apparatus (MRI-OA) was the objective tool. The olfactory bulb volume (OBV) and the olfactory sulcus depth (OSD) were quantified. ResultsBased on the COFT, 36 patients were categorized as having normosmic CHH (nCHH), and the other 35 patients were categorized as having Kallmann syndrome (KS). Among nCHH patients, 35 patients were classified as having normal olfaction and 1 patient had abnormal olfaction by SROS. For KS patients, there were 30 patients grouped into abnormal olfaction, while 5 patients had normal olfaction by SROS. For MRI-OA, 67% (18/27) of nCHH patients showed normal olfactory apparatus, and 33% (9/27) showed bilateral or unilateral olfactory bulb aplasia or hypoplasia. Among KS patients, 96% (27/28) of patients showed bilateral olfactory bulb hypoplasia or aplasia, and 4% (1/28) of patients showed normal olfactory apparatus. All six patients with unilateral olfactory bulb aplasia and three patients with bilateral olfactory bulb aplasia showed normal olfactory function. The accuracy of the SROS in the diagnosis of nCHH and KS was 91.5%, with a sensitivity of 0.857 and a specificity of 0.972, while the accuracy of MRI-OA is 92.7%, with a sensitivity of 0.964 and a specificity of 0.889. ConclusionSROS and MRI-OA both showed high accuracy to distinguish between KS and nCHH. The abnormal structure of the olfactory apparatus was relatively common in nCHH patients. CHH patients with unilateral olfactory bulb aplasia dysplasia usually had normal olfaction. Normal olfaction without apparent olfactory bulbs is rare but occurred in male CHH patients. |
收录类别 | SCI |
WOS关键词 | GONADOTROPIN-RELEASING-HORMONE ; KALLMANN-SYNDROME ; BULB VOLUME ; CLINICAL-ASSESSMENT ; BRAIN ; DYSFUNCTION ; ORTHONASAL ; DEFICIENCY ; MUTATIONS ; GENETICS |
资助项目 | Natural Science Foundation of Beijing ; [7212080] ; [7202151] |
WOS研究方向 | Endocrinology & Metabolism |
语种 | 英语 |
出版者 | FRONTIERS MEDIA SA |
WOS记录号 | WOS:000862455800001 |
资助机构 | Natural Science Foundation of Beijing |
源URL | [http://ir.psych.ac.cn/handle/311026/43625] |
专题 | 心理研究所_脑与认知科学国家重点实验室 |
通讯作者 | Wu, Xueyan |
作者单位 | 1.Peking Union Med Coll Hosp, Chinese Acad Med Sci, Peking Union Med Coll, Dept Radiol, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China 3.Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Peking Union Med Coll Hosp, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Yu, Bingqing,Chen, Kepu,Mao, Jiangfeng,et al. The diagnostic value of the olfactory evaluation for congenital hypogonadotropic hypogonadism[J]. FRONTIERS IN ENDOCRINOLOGY,2022,13:10. |
APA | Yu, Bingqing.,Chen, Kepu.,Mao, Jiangfeng.,Hou, Bo.,You, Hui.,...&Wu, Xueyan.(2022).The diagnostic value of the olfactory evaluation for congenital hypogonadotropic hypogonadism.FRONTIERS IN ENDOCRINOLOGY,13,10. |
MLA | Yu, Bingqing,et al."The diagnostic value of the olfactory evaluation for congenital hypogonadotropic hypogonadism".FRONTIERS IN ENDOCRINOLOGY 13(2022):10. |
入库方式: OAI收割
来源:心理研究所
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