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Dimethyl phthalate inhibits the growth of Escherichia coli K-12 by regulating sugar transport and energy metabolism

文献类型：期刊论文

作者Chen, Wenjing2,3; Zhao, Xiaosong2,3; Xu, Weihui2,3; Hu, Yunlong2,3; Hou, Ruixing1; Wang, Zhigang2,3
刊名ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
出版日期2022-09-22
页码9
ISSN号0944-1344
关键词Dimethyl phthalate Escherichia coli K-12 Sugar transporters Toxicity mechanism Computer simulation Carbon metabolic pathway
DOI10.1007/s11356-022-23083-9
通讯作者Wang, Zhigang(wangzhigang@qqhru.edu.cn)
英文摘要Dimethyl phthalate (DMP) is one of the most widely used plasticizers, and it is easily released into the environment, posing a threat to microbes. In this study, the impact of DMP on the uptake and metabolism of sugars in E. coli K-12 was assessed using proteomics, computational simulation analysis, transcriptome analysis, and sugar utilization experiments. DMP contamination inhibited the growth of E. coli K-12 and downregulated the expression of proteins in ATP-binding cassette (ABC) transporters and the phosphotransferase (PTS) system of E. coli K-12, which are primarily involved in the transmembrane transport of sugars. DMP formed a stable complex with sugar transporters and changed the rigidity and stability of the proteins. Furthermore, DMP treatment decreased the utilization of L-arabinose, glucose, D-xylose, and maltose. Moreover, carbon metabolism and oxidative phosphorylation were also downregulated by DMP. Our study shows that DMP reduces the uptake of sugars and ATP production and subsequently inhibits the growth of E. coli K-12.
WOS关键词XYLOSE BINDING-PROTEIN ; ACID ESTERS ; DEGRADATION ; CARBON
资助项目Natural Science Foundation of China[31670375] ; Strategic Priority Science and Technology Project of Chinese Academy of Sciences[XDA23050102]
WOS研究方向Environmental Sciences & Ecology
语种英语
出版者SPRINGER HEIDELBERG
WOS记录号WOS:000857690800006
资助机构Natural Science Foundation of China ; Strategic Priority Science and Technology Project of Chinese Academy of Sciences
源URL[http://ir.igsnrr.ac.cn/handle/311030/185424]  
专题中国科学院地理科学与资源研究所
通讯作者Wang, Zhigang
作者单位1.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Key Lab Ecosyst Network Observat & Modeling, Beijing 100101, Peoples R China
2.Qiqihar Univ, Sch Life Sci & Agr Forestry, Qiqihar 161006, Heilongjiang, Peoples R China
3.Heilongjiang Prov Technol Innovat Ctr Agromicrobi, Qiqihar 161006, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Wenjing,Zhao, Xiaosong,Xu, Weihui,et al. Dimethyl phthalate inhibits the growth of Escherichia coli K-12 by regulating sugar transport and energy metabolism[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2022:9.
APA Chen, Wenjing,Zhao, Xiaosong,Xu, Weihui,Hu, Yunlong,Hou, Ruixing,&Wang, Zhigang.(2022).Dimethyl phthalate inhibits the growth of Escherichia coli K-12 by regulating sugar transport and energy metabolism.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,9.
MLA Chen, Wenjing,et al."Dimethyl phthalate inhibits the growth of Escherichia coli K-12 by regulating sugar transport and energy metabolism".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022):9.

入库方式： OAI收割

来源：地理科学与资源研究所

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