Obective: To explore the characteristics of response inhibition to emotional facial expressions and its relationship to anhedonia under both explicit and implicit conditions in patients with major depressive disorder (MDD). Methods: The ability of response inhibition of 38 patients with MDD meeting the diagnostic criteria of DSM-5 and 40 normal controls were assessed by a stop signal task combined with facial stimuli under explicit and implicit emotional conditions. The Chapman Social Anhedonia Scale and Chapman Physical Anhedonia Scale (CSAS&CPAS) was used to evaluate the severity of anhedonia, and the 24-item Hamilton Depression Rating Scale (HAMD-24) was used to evaluate the severity of depression. Mixed-model ANOVA was used for statistical analysis of intra-group and inter-group differences. Results: Under the explicit condition, the stop-signal reaction time (SS- RT)[X296. 2士10. 3) ma vs. (242.1士10. 1) ms, P<0. 001 ] was longer, the Probability of Inhibition ( PI)[(0. 51士0. 01) vs.(0. 55士0. O1) ] was lower and the Stop Signal Delay time(SSD) [(246. 5士13.4) ms vs. (311.4士13. 0) ms] were shorter in the MDD group than in the control group ( P.s<0. O1) . Under the implicit condition, the SSRTP[(292. 4士10. 8) me vs.(230. 2士10. 5) ms, P < 0. 001 ] was higher, the PI[ (0. 52士0.01)vs. (0.55士0.01)] was lower, and the SSD time[(266. 9士13. 7) ms vs. (324. 4士13. 3) ms] was shorter in the MDD group than in the control group(凡<0. OS). The SSRT of explicit neutral(r=0. 38) and sad face (r=0. 36)，and implicit neutral ( r =0. 43 ) and sad face ( r=0. 39) were significantly positively correlated with the CSAS敌'PAS anhedonia scores in the MDD group. Conclusion: The results suggest that both explicit and implicit emotional response inhibition in pabents with major depressive disorder, which may be related to the severity of anhedonia.

目的:探究抑郁症患者外显及内隐情绪面孔反应抑制的特点及其与快感缺失的关系。方法:采用情绪面孔停止信号任务测评38例符合DSM-5诊断标准的抑郁症患者及40例正常对照在外显和内隐条件下的反应抑制能力。采用Chapman社会和躯体快感缺失量表(CSAS&CPAS)评估快感缺失水平,采用汉密顿抑郁量表(HAMD-24)评估患者抑郁程度。采用混合模型方差分析组内和组间的差异。结果:在外显任务中,抑郁症组的停止信号反应时(SSRT)大于正常对照组[(296.2±10.3) ms vs.(242.1±10.1)ms,P

教育部人文社会科学研究规划基金项目(19YJA190006);; 山东省自然科学基金(ZR2017LC023);; 山东省研究生教育质量提升计划(SDYY18149);; 大学生科技创新基金项目(S202010438041)