Association between MnSOD Activity and Cognitive Impairment in Unmedicated First-Episode Schizophrenia: Regulated by MnSOD Ala-9Val Gene Polymorphism
文献类型：期刊论文
| 作者 | Wang, Dong Mei2,3; Zhu, Rong Rong2,3; Tian, Yang2,3; Uludag, Kadir2,3; Chen, Jia Jing3; Zhou, Hui Xia2,3; Wang, Li2,3 ; Kosten, Thomas R.1; Zhang, Xiang Yang2,3
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| 刊名 | ANTIOXIDANTS
 |
| 出版日期 | 2022-10-01 |
| 卷号 | 11期号:10页码:13 |
| 关键词 | schizophrenia MnSOD cognitive function Ala-9Val polymorphism |
| DOI | 10.3390/antiox11101981 |
| 通讯作者 | Zhang, Xiang Yang(zhangxy@psych.ac.cn) |
| 英文摘要 | The imbalance between pro-oxidants and antioxidants is thought to be responsible for aging and cognitive impairment in many degenerative diseases, including schizophrenia (SZ). As the first antioxidant enzyme to detoxify superoxide radicals in mitochondria, manganese superoxide dismutase (MnSOD) activity and its functional polymorphism of Ala-9Val have been found to be associated with SZ. In this study, we explored the association between MnSOD activity, MnSOD Ala-9Val polymorphism and cognitive dysfunction in unmedicated first-episode (UMFE) SZ patients, which has not been examined. We recruited 234 UMFE SZ patients and 232 healthy controls (HC) and evaluated them with Repeated Battery for the Assessment of Neuropsychological Status (RBANS), plasma MnSOD activity and MnSOD Ala-9Val (rs4880) polymorphism. In addition, we used the Positive and Negative Syndrome Scale (PANSS) to assess the severity of patients' psychopathological symptoms. Compared with HC, UMFE patients showed extensive cognitive impairment on RBANS, and had higher MnSOD activity. MnSOD Ala-9Val polymorphism was not associated with SZ susceptibility and cognitive impairment, but only affected MnSOD activity in patients. Moreover, only in SZ patients with Val homozygotes, MnSOD activity was significantly correlated with cognitive impairment, especially in RBANS total score, visuospatial/constructional and attention index scores. Our results suggest that cognitive impairment is associated with MnSOD activity in patients with first-episode SZ, which may be regulated by MnSOD Ala-9Val polymorphism. |
| 收录类别 | SCI |
| WOS关键词 | MANGANESE SUPEROXIDE-DISMUTASE ; MEDIATED IMMUNE ACTIVATION ; LONG-TERM POTENTIATION ; OXIDATIVE STRESS ; ANTIOXIDANT CAPACITY ; SYNAPTIC PLASTICITY ; TARDIVE-DYSKINESIA ; DEFICITS ; DISEASE ; AGE |
| 资助项目 | National Natural Science Foundation of China[31300848] ; CAS International Cooperation Research Program[153111KYSB20190004] ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Food Science & Technology |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:000872002600001 |
| 资助机构 | National Natural Science Foundation of China ; CAS International Cooperation Research Program ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health |
| 源URL | [http://ir.psych.ac.cn/handle/311026/43779]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Xiang Yang |
| 作者单位 | 1.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Dong Mei,Zhu, Rong Rong,Tian, Yang,et al. Association between MnSOD Activity and Cognitive Impairment in Unmedicated First-Episode Schizophrenia: Regulated by MnSOD Ala-9Val Gene Polymorphism[J]. ANTIOXIDANTS,2022,11(10):13. |
| APA | Wang, Dong Mei.,Zhu, Rong Rong.,Tian, Yang.,Uludag, Kadir.,Chen, Jia Jing.,...&Zhang, Xiang Yang.(2022).Association between MnSOD Activity and Cognitive Impairment in Unmedicated First-Episode Schizophrenia: Regulated by MnSOD Ala-9Val Gene Polymorphism.ANTIOXIDANTS,11(10),13. |
| MLA | Wang, Dong Mei,et al."Association between MnSOD Activity and Cognitive Impairment in Unmedicated First-Episode Schizophrenia: Regulated by MnSOD Ala-9Val Gene Polymorphism".ANTIOXIDANTS 11.10(2022):13. |
入库方式： OAI收割
来源：心理研究所
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