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Association of serum lipid levels with psychotic symptoms in young, first-episode and drug naive outpatients with major depressive disorder: A large-scale cross-sectional study

文献类型：期刊论文

作者Yan, Lijuan6; Kang, Chuanyi5; Wang, Xiaohong5; Yang, Liying5; Zhao, Na2,5; Zhang, Xiangyang1,3,4
刊名PSYCHIATRY RESEARCH
出版日期2022-11-01
卷号317页码:5
ISSN号0165-1781
关键词Serum lipid Psychotic symptoms Young Major depressive disorder
DOI10.1016/j.psychres.2022.114864
通讯作者Zhao, Na(zhaona@hrbmu.edu.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Background: Major depressive disorder (MDD) patients with psychotic symptoms have more complex clinical symptoms and higher relapse rates. The purpose of this study was to compare serum lipid differences between psychotic major depressive disorder (PMD) and non-psychotic major depressive disorder (NPMD) in a large sample of young first-episode drug naive (FEDN) patients. Methods: We recruited 1289 young MDD patients. Socio-demographic information, clinical data, and lipid pa-rameters were collected. The Hamilton Depression Rating Scale, the Hamilton Anxiety Rating Scale, and the positive symptom subscale of the Positive and Negative Syndrome Scale were used to assess patients' depressive, anxiety and psychotic symptoms, respectively.Results: Compared with the NPMD group, the PMD group had higher HAMD, HAMA scores, and higher TC, TG, and LDL-C levels. Correlation analysis showed that psychotic symptoms were significantly associated with the total score of HAMD and HAMA, and the levels of serum lipid. In addition, logistic regression analysis found that TC was associated with psychotic symptoms in young FEDN MDD patients.Conclusion: Our results suggest TC levels may be associated with psychotic symptoms in young MDD patients. The importance of regular psychotic symptom assessment in young MDD patients with high TC levels should be taken into account.
收录类别SCI
WOS关键词UNIPOLAR DEPRESSION ; NEGATIVE SYMPTOMS ; RATING-SCALE ; SCHIZOPHRENIA ; ADOLESCENTS ; CHALLENGES ; DIAGNOSIS ; HDL
资助项目basic scientific research business expenses of Heilongjiang Provincial Colleges and universities in 2021[2021-KYYWF-0223] ; First Affiliated Hospital of Harbin Medical University[2021B22]
WOS研究方向Psychiatry
语种英语
出版者ELSEVIER IRELAND LTD
WOS记录号WOS:000869736500024
资助机构basic scientific research business expenses of Heilongjiang Provincial Colleges and universities in 2021 ; First Affiliated Hospital of Harbin Medical University
源URL[http://ir.psych.ac.cn/handle/311026/43785]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhao, Na; Zhang, Xiangyang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Harbin Med Univ, Dept Psychiat, Affiliated Hosp 1, 23 Youzheng St, Harbin 150001, Heilongjiang, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Harbin Med Univ, Affiliated Hosp 1, Dept Psychiat, Harbin, Heilongjiang, Peoples R China
6.Harbin Med Univ, Affiliated Hosp 4, Dept Psychiat & Psychol, Harbin, Heilongjiang, Peoples R China
推荐引用方式
GB/T 7714		 Yan, Lijuan,Kang, Chuanyi,Wang, Xiaohong,et al. Association of serum lipid levels with psychotic symptoms in young, first-episode and drug naive outpatients with major depressive disorder: A large-scale cross-sectional study[J]. PSYCHIATRY RESEARCH,2022,317:5.
APA Yan, Lijuan,Kang, Chuanyi,Wang, Xiaohong,Yang, Liying,Zhao, Na,&Zhang, Xiangyang.(2022).Association of serum lipid levels with psychotic symptoms in young, first-episode and drug naive outpatients with major depressive disorder: A large-scale cross-sectional study.PSYCHIATRY RESEARCH,317,5.
MLA Yan, Lijuan,et al."Association of serum lipid levels with psychotic symptoms in young, first-episode and drug naive outpatients with major depressive disorder: A large-scale cross-sectional study".PSYCHIATRY RESEARCH 317(2022):5.

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来源：心理研究所

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