Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI study
文献类型：期刊论文
| 作者 | Canete-Masse, Cristina7,8; Carbo-Carrete, Maria5,6; Pero-Cebollero, Maribel5,7,8; Cui, Shi-Xian1,2,3,4; Yan, Chao-Gan1,2,3,4 ; Guardia-Olmos, Joan5,7,8
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| 刊名 | INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
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| 出版日期 | 2023 |
| 卷号 | 23期号:1页码:11 |
| ISSN号 | 1697-2600 |
| 关键词 | Down syndrome Degree centrality Seed-based functional connectivity Brain networks connectivity Functional |
| DOI | 10.1016/j.ijchp.2022.100341 |
| 通讯作者 | Canete-Masse, Cristina(cristinacanete@ub.edu) |
| 英文摘要 | Background/Objective: Neuroimaging studies have shown brain abnormalities in Down syndrome (DS) but have not clarified the underlying mechanisms of dysfunction. Here, we investigated the degree centrality (DC) abnormalities found in the DS group compared with the control group, and we conducted seed-based functional connectivity (FC) with the significant clusters found in DC. Moreover, we used the significant clusters of DC and the seed-based FC to elucidate differences between brain networks in DS compared with controls. Method: The sample comprised 18 persons with DS (M = 28.67, SD = 4.18) and 18 controls (M = 28.56, SD = 4.26). Both samples underwent rest-ing-state functional magnetic resonance imaging. Results: DC analysis showed increased DC in the DS in temporal and right frontal lobe, as well as in the left caudate and rectus and decreased DC in the DS in regions of the left frontal lobe. Regarding seed-based FC, DS showed increased and decreased FC. Significant differences were also found between networks using Yeo parcellations, showing both hyperconnectivity and hypoconnectivity between and within networks. Conclusions: DC, seed-based FC and brain networks seem altered in DS, finding hypo-and hyperconnectivity depending on the areas. Network analysis revealed between-and within-network differences, and these abnormalities shown in DS could be related to the characteristics of the population. (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| 收录类别 | SCI |
| WOS关键词 | SMALL-WORLD ; ORGANIZATION ; ADULTS ; IMPACT ; MRI |
| 资助项目 | Spanish Ministry of Science, Innovation and Universities ; [PGC2018-095829-B-I00] |
| WOS研究方向 | Psychology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE INC |
| WOS记录号 | WOS:000871483800001 |
| 资助机构 | Spanish Ministry of Science, Innovation and Universities |
| 源URL | [http://ir.psych.ac.cn/handle/311026/43770]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 通讯作者 | Canete-Masse, Cristina |
| 作者单位 | 1.Univ Chinese Acad Sci, Sino Danish Coll, Sino Danish Ctr Educ & Res, Beijing, Peoples R China 2.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China 3.Chinese Acad Sci, Int Big Data Ctr Depress Res, Beijing, Peoples R China 4.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 5.Univ Barcelona, Inst Neurosci, Barcelona, Spain 6.Univ Barcelona, Fac Psychol, Dept Cognit Dev & Educ Psychol, Barcelona, Spain 7.Univ Barcelona, UB Inst Complex Syst, Barcelona, Spain 8.Univ Barcelona, Fac Psychol, Dept Social Psychol & Quantitat Psychol, Barcelona, Spain |
| 推荐引用方式 GB/T 7714 | Canete-Masse, Cristina,Carbo-Carrete, Maria,Pero-Cebollero, Maribel,et al. Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI study[J]. INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY,2023,23(1):11. |
| APA | Canete-Masse, Cristina,Carbo-Carrete, Maria,Pero-Cebollero, Maribel,Cui, Shi-Xian,Yan, Chao-Gan,&Guardia-Olmos, Joan.(2023).Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI study.INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY,23(1),11. |
| MLA | Canete-Masse, Cristina,et al."Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI study".INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY 23.1(2023):11. |
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来源：心理研究所
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