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Mililatensols A-C, New Records of Sarsolenane and Capnosane Diterpenes from Soft Coral Sarcophyton mililatensis

文献类型：期刊论文

作者Bu, Qing6; Yang, Min5; Yan, Xian-Yun6; Li, Song-Wei5; Ge, Zeng-Yue6; Zhang, Ling6; Yao, Li-Gong5; Guo, Yue-Wei1,2,3,4,5; Liang, Lin-Fu6
刊名MARINE DRUGS
出版日期2022-09-01
卷号20期号:9页码:10
关键词soft coral Sarcophyton mililatensis sarsolenane capnosane stereochemistry anti-inflammatory activity
DOI10.3390/md20090566
通讯作者Guo, Yue-Wei(ywguo@simm.ac.cn) ; Liang, Lin-Fu(lianglinfu@csuft.edu.cn)
英文摘要Three unusual diterpenes with rare sarsolenane and capnosane skeletons, namely mililatensols A-C (1-3), were isolated from the South China Sea soft coral Sarcophyton mililatensis, leading to the first record of sarsolenane and capnosane diterpenes from the title animal. The structures of compounds 1-3 were established by extensive spectroscopic analysis and comparison with the literature data. Moreover, the absolute configuration of 2 was determined by TDDFT ECD calculations. In an in vitro bioassay, none of the isolated compounds showed obvious anti-inflammatory activity on LPS-induced TNF-alpha release in RAW264.7 macrophages. In the preliminary virtual screening of inhibitory potential against SARS-CoV-2 by molecular docking, the results showed these three diterpenes were potential SARS-CoV-2 M-pro inhibitors.
WOS关键词TROCHELIOPHORUM ; CEMBRANOIDS
资助项目National Natural Science Foundation of China (NSFC)[41876194] ; National Natural Science Foundation of China (NSFC)[81991521] ; SKLDR/SIMM Project[SIMM2103ZZ-06]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000857506200001
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/302477]  
专题新药研究国家重点实验室
通讯作者Guo, Yue-Wei; Liang, Lin-Fu
作者单位1.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
2.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
6.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Peoples R China
推荐引用方式
GB/T 7714		 Bu, Qing,Yang, Min,Yan, Xian-Yun,et al. Mililatensols A-C, New Records of Sarsolenane and Capnosane Diterpenes from Soft Coral Sarcophyton mililatensis[J]. MARINE DRUGS,2022,20(9):10.
APA Bu, Qing.,Yang, Min.,Yan, Xian-Yun.,Li, Song-Wei.,Ge, Zeng-Yue.,...&Liang, Lin-Fu.(2022).Mililatensols A-C, New Records of Sarsolenane and Capnosane Diterpenes from Soft Coral Sarcophyton mililatensis.MARINE DRUGS,20(9),10.
MLA Bu, Qing,et al."Mililatensols A-C, New Records of Sarsolenane and Capnosane Diterpenes from Soft Coral Sarcophyton mililatensis".MARINE DRUGS 20.9(2022):10.

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来源：上海药物研究所

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