J-aggregates albumin-based NIR-II fluorescent dye nanoparticles for cancer phototheranostics
文献类型：期刊论文
| 作者 | Du, Bulin3,4,7; Liu, Ruiqi2; Qu, Chunrong3,4; Qian, Kun3,4; Suo, Yongkuan2; Wu, Fengxia2; Chen, Hongda1; Li, Xuena7; Li, Yaming7; Liu, Hongguang2 |
| 刊名 | MATERIALS TODAY BIO
 |
| 出版日期 | 2022-12-01 |
| 卷号 | 16页码:10 |
| 关键词 | IR1061 Human serum albumin Nanoparticles Second near-infrared window Fluorescence imaging Photothermal therapy |
| ISSN号 | 2590-0064 |
| DOI | 10.1016/j.cj.2022.03.009 |
| 通讯作者 | Li, Yaming(ymli2001@163.com) ; Liu, Hongguang(simonliu@mail.neu.edu.cn) ; Cheng, Zhen(zcheng@simm.ac.cn) |
| 英文摘要 | Phototheranostics, relying on energy conversions of fluorophores upon excitation, integrating diagnostic fluorescence imaging and photo-driven therapy, represents a promising strategy for cancer precision medicine. Compared with the first near-infrared biological window (NIR-I), fluorophores imaged in the second window (NIR-II, 1000-1700 nm) exhibit a higher temporal and spatial resolution and tissue penetration depth. Polymethine cyanine-based dye IR1061 is a typical NIR-II small-molecule organic fluorophore, but its low water solubility and short circulation time limiting its biological applications. Therefore, human serum albumin (HSA) nanoparticles with great biocompatibility and biosafety were employed to fabricate hydrophobic IR1061, which exhibited red-shifted absorption band as typical for J-aggregates. Moreover, IR1061@HSA nanoparticles can be successfully used for NIR-II imaging to noninvasively visualize the tumor vascular networks, as well as real-time intraoperative image-guided tumor resection. Interestingly, benefiting from the high photothermal conversion efficiency brought by J-aggregates, IR1061@HSA nanoparticles were also explored for photothermal therapy (PTT) and cause efficient thermal ablation of tumors. Overall, IR1061@HSA, as a novel J-aggregates albuminbased NIR II dye nanoparticle with high biocompatibility, provides an integrated versatile platform for cancer phototheranostics with promising clinical translation prospects. |
| WOS关键词 | HUMAN SERUM-ALBUMIN ; INDOCYANINE GREEN ; EMISSION ; STRATEGY |
| 资助项目 | Department of Radiology, Stanford University ; National Natural Science Foundation of China[82171987] ; National Natural Science Foundation of China[81971652] ; National Natural Science Foundation of China[81761148029] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000856546900002 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302480]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Yaming; Liu, Hongguang; Cheng, Zhen |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130000, Peoples R China 2.Northeastern Univ, Coll Life & Hlth Sci, Inst Mol Med, Shenyang 110000, Peoples R China 3.Stanford Univ, Sch Med, Bio X Program, Stanford, CA 94305 USA 4.Stanford Univ, Canary Ctr Stanford Canc Early Detect, Sch Med, Dept Radiol,Mol Imaging Program & Stanford MIPS, Stanford, CA 94305 USA 5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264000, Peoples R China 6.Chinese Acad Sci, Mol Imaging Ctr, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 7.China Med Univ, Hosp 1, Dept Nucl Med, 155 North Nanjing St, Shenyang 110001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Bulin,Liu, Ruiqi,Qu, Chunrong,et al. J-aggregates albumin-based NIR-II fluorescent dye nanoparticles for cancer phototheranostics[J]. MATERIALS TODAY BIO,2022,16:10. |
| APA | Du, Bulin.,Liu, Ruiqi.,Qu, Chunrong.,Qian, Kun.,Suo, Yongkuan.,...&Cheng, Zhen.(2022).J-aggregates albumin-based NIR-II fluorescent dye nanoparticles for cancer phototheranostics.MATERIALS TODAY BIO,16,10. |
| MLA | Du, Bulin,et al."J-aggregates albumin-based NIR-II fluorescent dye nanoparticles for cancer phototheranostics".MATERIALS TODAY BIO 16(2022):10. |
入库方式： OAI收割
来源：上海药物研究所
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