Discovery and photosynthesis of sinuaustones A and B, diterpenoids with a novel carbon scaffold isolated from soft coral Sinularia australiensis from Hainan
文献类型：期刊论文
| 作者 | Wu, Meng-Jun4,5,6; Yu, Dan-Dan3; Su, Ming-Zhi3; Wang, Jian-Rong4 ; Gong, Lei2; Zhang, Zai-Yong4; Wang, Hong5,6; Guo, Yue-Wei1,3,4,5,6
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
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| 出版日期 | 2022-09-22 |
| 页码 | 8 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/d2go01265k |
| 通讯作者 | Wang, Hong(hongw@zjut.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
| 英文摘要 | Two novel diterpenoids, sinuaustones A (1) and B (2), featuring an unprecedented tricyclo[9.3.1.0(3.15)]tetradecane carbon framework, along with a new spatane-type diterpenoid 3 and two related known compounds 4 and 5, were isolated from the South China Sea soft coral Sinularia australiensis. The structures of the new compounds were established by detailed spectroscopic, X-ray diffraction analysis and quantum chemical computation methods. Photosynthesis of 1 and 2 starting from co-isolated 5 was completed giving insight into the plausible biosynthetic pathway of 1 and 2, as well as their structural relationship with co-occurring 3-5. In the in vitro bioassay, compounds 1, 2, 3, and 5 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW264.7 cells with IC50 values of 20.9, 75.1, 9.1, and 30.4 mu M, respectively. |
| 资助项目 | National Natural Science Foundation of China[81991521] ; SKLDR/SIMM Project[SIMM2013ZZ-06] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000856184300001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302489]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Hong; Guo, Yue-Wei |
| 作者单位 | 1.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, Qingdao 266237, Peoples R China 2.Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China 6.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Meng-Jun,Yu, Dan-Dan,Su, Ming-Zhi,et al. Discovery and photosynthesis of sinuaustones A and B, diterpenoids with a novel carbon scaffold isolated from soft coral Sinularia australiensis from Hainan[J]. ORGANIC CHEMISTRY FRONTIERS,2022:8. |
| APA | Wu, Meng-Jun.,Yu, Dan-Dan.,Su, Ming-Zhi.,Wang, Jian-Rong.,Gong, Lei.,...&Guo, Yue-Wei.(2022).Discovery and photosynthesis of sinuaustones A and B, diterpenoids with a novel carbon scaffold isolated from soft coral Sinularia australiensis from Hainan.ORGANIC CHEMISTRY FRONTIERS,8. |
| MLA | Wu, Meng-Jun,et al."Discovery and photosynthesis of sinuaustones A and B, diterpenoids with a novel carbon scaffold isolated from soft coral Sinularia australiensis from Hainan".ORGANIC CHEMISTRY FRONTIERS (2022):8. |
入库方式： OAI收割
来源：上海药物研究所
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