A c-MET-Targeted Topical Fluorescent Probe cMBP-ICG Improves Oral Squamous Cell Carcinoma Detection in Humans
文献类型：期刊论文
| 作者 | Wang, Jingbo5; Li, Siyi4; Wang, Kun3; Zhu, Ling5; Yang, Lin5; Zhu, Yunjing5; Zhang, Zhen4; Hu, Longwei4; Yuan, Yuan5; Fan, Qi5 |
| 刊名 | ANNALS OF SURGICAL ONCOLOGY
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| 出版日期 | 2022-10-02 |
| 页码 | 11 |
| ISSN号 | 1068-9265 |
| DOI | 10.1245/s10434-022-12532-x |
| 通讯作者 | Yuan, Ying(yuany83@163.com) ; Huang, Ruimin(rmhuang@simm.ac.cn) ; Tian, Jie(tian@ieee.org) ; Tao, Xiaofeng(cjr.taoxiaofeng@vip.163.com) |
| 英文摘要 | Introduction The postoperative survival of oral squamous cell carcinoma (SCC) relies on precise detection and complete resection of original tumors. The mucosal extension of the tumor is evaluated visually during surgery, but small and flat foci are difficult to detect. Real-time fluorescence imaging may improve detection of tumor margins. Materials and Methods In the current study, a peptide-based near-infrared (NIR) fluorescence dye, c-MET-binding peptide-indocyanine green (cMBP-ICG), which specifically targets tumor via c-MET binding, was synthetized. A prospective pilot clinical trial then was conducted with oral SCC patients and intraoperatively to assess the feasibility of cMBP-ICG used to detect tumors margins. Fluorescence was histologically correlated to determine sensitivity and specificity. Results The immunohistochemistry (IHC) results demonstrated increased c-Met expression in oral SCC compared with normal mucosa. Tumor-to-background ratios ranged from 2.71 +/- 0.7 to 3.11 +/- 1.2 in different concentration groups. From 10 patients with oral SCC, 60 specimens were collected from tumor margins. The sensitivity and specificity of discriminative value derived from cMBP-ICG application in humans were respectively 100% and 75%. Conclusions Topical application of cMBP-ICG is feasible and safe for optimizing intraoperative visualization and tumor margin detection in oral SCC patients, which could clinically increase the probability of complete resections and improve oncologic outcomes. |
| WOS关键词 | HEAD ; CANCER ; NANOPARTICLES ; OROPHARYNGEAL ; PROGRESSION ; EXPRESSION |
| 资助项目 | National Natural Science Foundation of China[91859202] ; National Natural Science Foundation of China[82172049] ; National Natural Science Foundation of China[91859106] ; National Natural Science Foundation of China[82172001] |
| WOS研究方向 | Oncology ; Surgery |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000863965500002 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302604]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yuan, Ying; Huang, Ruimin; Tian, Jie; Tao, Xiaofeng |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Pathol, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, Shanghai, Peoples R China 3.Chinese Acad Sci, Beijing Key Lab Mol Imaging, Inst Automat,State Key Lab Management & Control, CAS Key Lab Mol Imaging, Beijing, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Oral & Maxillofacial Head & Neck Oncol, Shanghai, Peoples R China 5.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Radiol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jingbo,Li, Siyi,Wang, Kun,et al. A c-MET-Targeted Topical Fluorescent Probe cMBP-ICG Improves Oral Squamous Cell Carcinoma Detection in Humans[J]. ANNALS OF SURGICAL ONCOLOGY,2022:11. |
| APA | Wang, Jingbo.,Li, Siyi.,Wang, Kun.,Zhu, Ling.,Yang, Lin.,...&Tao, Xiaofeng.(2022).A c-MET-Targeted Topical Fluorescent Probe cMBP-ICG Improves Oral Squamous Cell Carcinoma Detection in Humans.ANNALS OF SURGICAL ONCOLOGY,11. |
| MLA | Wang, Jingbo,et al."A c-MET-Targeted Topical Fluorescent Probe cMBP-ICG Improves Oral Squamous Cell Carcinoma Detection in Humans".ANNALS OF SURGICAL ONCOLOGY (2022):11. |
入库方式： OAI收割
来源：上海药物研究所
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