Identification of ST3GAL5 as a prognostic biomarker correlating with CD8(+) T cell exhaustion in clear cell renal cell carcinoma
文献类型：期刊论文
| 作者 | Liu, Jiakuan4,5; Li, Meiqian3,5; Wu, Jiajun4; Qi, Qi4; Li, Yang5; Wang, Simei1,2; Liang, Shengjie5; Zhang, Yuqing5; Zhu, Zhitao4; Huang, Ruimin1,2
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| 刊名 | FRONTIERS IN IMMUNOLOGY
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| 出版日期 | 2022-09-12 |
| 卷号 | 13页码:14 |
| 关键词 | sialylation clear cell renal cell carcinoma ST3GAL5 CD8(+) T cell exhaustion prognostic biomarker |
| ISSN号 | 1664-3224 |
| DOI | 10.3389/fimmu.2022.979605 |
| 通讯作者 | Huang, Ruimin(rmhuang@simm.ac.cn) ; Yan, Jun(yan_jun@fudan.edu.cn) ; Zhu, Rujian(20667@shpdh.org) |
| 英文摘要 | Aberrant sialylation is frequently observed in tumor development, but which sialyltransferases are involved in this event are not well known. Herein, we performed comprehensive analyses on six ST3GAL family members, the alpha-2,3 sialyltransferases, in clear cell renal cell carcinoma (ccRCC) from public datasets. Only ST3GAL5 was consistently and significantly overexpressed in ccRCC (n = 791 in total), compared with normal kidney tissues. Its overexpression was positively correlated with tumor stage, grade, and the poor prognosis in ccRCC patients. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses indicated the involvement of ST3GAL5 in tumor immunoregulation. Then we revealed that ST3GAL5 expression showed a positive correlation with CD8(+) T cell infiltration, using multiple tools on TIMER2.0 web server. Notably, ST3GAL5 overexpression was further identified to be associated with expression signature of CD8(+) T cell exhaustion in ccRCC samples from three datasets (n = 867 in total; r > 0.3, p < 0.001). In our own ccRCC cohort (n = 45), immunohistochemistry and immunofluorescence staining confirmed that ST3GAL5 overexpression was accompanied by high CD8(+) T cell infiltration with the increased exhaustion markers. Altogether, ST3GAL5 as a promising prognostic biomarker with CD8(+) T cell exhaustion in ccRCC is indicated. |
| WOS关键词 | CANCER STATISTICS ; GENE-EXPRESSION ; SIALYLTRANSFERASE ; SIALYLATION ; BLOCKADE ; PATTERNS ; INVASION ; BIOLOGY ; GROWTH |
| 资助项目 | National Natural Science Foundation of China[82172001] ; National Natural Science Foundation of China[82103415] ; Shanghai Municipal Science and Technology Major Project ; Shanghai Science and Technology Committee[20S11901400] ; Shanghai Municipal Health Commission Project[202140267] ; Talents Training Program of Pudong Hospital affiliated to Fudan University[PY202001] ; Project of Key Medical Discipline of Pudong Hospital of Fudan University[Zdxk2020-04] ; Project of Key Medical Specialty and Treatment Center of Pudong Hospital of Fudan University[Zdzk2020-01] |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000861612200001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302616]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Huang, Ruimin; Yan, Jun; Zhu, Rujian |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Nanjing Univ, Model Anim Res Ctr, Nanjing, Jiangsu, Peoples R China 4.Fudan Univ, Dept Lab Anim Sci, Shanghai, Peoples R China 5.Fudan Univ, Pudong Med Ctr, Shanghai Pudong Hosp, Dept Urol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jiakuan,Li, Meiqian,Wu, Jiajun,et al. Identification of ST3GAL5 as a prognostic biomarker correlating with CD8(+) T cell exhaustion in clear cell renal cell carcinoma[J]. FRONTIERS IN IMMUNOLOGY,2022,13:14. |
| APA | Liu, Jiakuan.,Li, Meiqian.,Wu, Jiajun.,Qi, Qi.,Li, Yang.,...&Zhu, Rujian.(2022).Identification of ST3GAL5 as a prognostic biomarker correlating with CD8(+) T cell exhaustion in clear cell renal cell carcinoma.FRONTIERS IN IMMUNOLOGY,13,14. |
| MLA | Liu, Jiakuan,et al."Identification of ST3GAL5 as a prognostic biomarker correlating with CD8(+) T cell exhaustion in clear cell renal cell carcinoma".FRONTIERS IN IMMUNOLOGY 13(2022):14. |
入库方式： OAI收割
来源：上海药物研究所
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