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Anti-inflammatory and PTP1B inhibitory sesquiterpenoids from the twigs and leaves of Aglaia lawii

文献类型：期刊论文

作者Xia, Ming-Jun4; Zhang, Meng4; Li, Song-Wei3; Cai, Zhe-Fei4; Zhao, Tian-Sheng4; Liu, Ai-Hong2; Luo, Jun1; Zhang, Hai-Yan3; Li, Jia3; Guo, Yue-Wei3
刊名FITOTERAPIA
出版日期2022-10-01
卷号162页码:7
ISSN号0367-326X
关键词Aglaia lawii Sesquiterpenoids Amouanglienoids A and B X-ray diffraction Anti-inflammatory activity PTP1B inhibitory activity
DOI10.1016/j.fitote.2022.105260
通讯作者Luo, Jun(174637426@qq.com) ; Wang, Bin(wbcy008@163.com) ; Mao, Shui-Chun(maoshuichun@ncu.edu.cn)
英文摘要Twelve sesquiterpenoids with seven different carbon skeletons, including four isodaucanes (1-4), an aromadendrane (5), a guaiane (6), a cadalane (7), two eudesmanes (8 and 9), two bisabolanes (10 and 11), and a megastigmane (12), were isolated from the twigs and leaves of Aglaia lawii (Wight) C. J. Saldanha et Ramamorthy. Of these compounds, amouanglienoids A (1) and B (2) are new isodaucane sesquiterpenoids. This is the first report of isodaucanes from the genus Aglaia, and amouanglienoid A (1) represents the first isodaucane containing a delta(7(8)) double bond. Their structures were discerned from extensive spectroscopic analyses, single -crystal X-ray diffraction, and comparison of the experimental and calculated ECD data. In in vitro bioassays, compounds 1, 10, and 11 showed potent inhibitory effects against lipopolysaccharide (LPS)-induced inflammation in BV-2 microglial cells, while compound 11 exhibited considerable inhibition of PTP1B with an IC50 value of 16.05 +/- 1.09 mu M.
WOS关键词ISODAUCANE SESQUITERPENES ; (+)-APHANAMOL-I ; DITERPENOIDS ; DERIVATIVES ; STEROIDS
资助项目National Natural Science Foundation of China[82060633] ; National Natural Science Foundation of China[81860616] ; National Natural Science Foundation of China[21362024] ; Natural Science Foundation of Jiangxi Province, China[20212ACB206034] ; Natural Science Foundation of Jiangxi Province, China[20202BAB206084] ; Natural Science Foundation of Jiangxi Province, China[20181BAB205086] ; State Key Laboratory of Drug Research-SIMM[SIMM1803KF-01]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者ELSEVIER
WOS记录号WOS:000862695700003
源URL[http://119.78.100.183/handle/2S10ELR8/302619]  
专题新药研究国家重点实验室
通讯作者Luo, Jun; Wang, Bin; Mao, Shui-Chun
作者单位1.Nanchang Univ, Affiliated Stomatol Hosp, Dept Orthodont, Key Lab Oral Biomed Jiangxi Prov, Nanchang 330006, Peoples R China
2.Nanchang Univ, Ctr Anal & Testing, Nanchang 330047, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Nanchang Univ, Sch Pharm, 461 Bayi Rd, Nanchang 330006, Peoples R China
推荐引用方式
GB/T 7714		 Xia, Ming-Jun,Zhang, Meng,Li, Song-Wei,et al. Anti-inflammatory and PTP1B inhibitory sesquiterpenoids from the twigs and leaves of Aglaia lawii[J]. FITOTERAPIA,2022,162:7.
APA Xia, Ming-Jun.,Zhang, Meng.,Li, Song-Wei.,Cai, Zhe-Fei.,Zhao, Tian-Sheng.,...&Mao, Shui-Chun.(2022).Anti-inflammatory and PTP1B inhibitory sesquiterpenoids from the twigs and leaves of Aglaia lawii.FITOTERAPIA,162,7.
MLA Xia, Ming-Jun,et al."Anti-inflammatory and PTP1B inhibitory sesquiterpenoids from the twigs and leaves of Aglaia lawii".FITOTERAPIA 162(2022):7.

入库方式： OAI收割

来源：上海药物研究所

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