Comparative proteomic and phosphoproteomic analysis of Mycobacteria treated with flavonoid quercetin and non-flavonoid caffeic acid
文献类型：期刊论文
| 作者 | Zhang, Mingya3,4; Liu, Quan2,3; Huang, Yuqi2,3; Wang, Le3,4; Tan, Minjia1,2,3,4 ; Xu, Jun-Yu1,2,3
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| 刊名 | INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
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| 出版日期 | 2022-12-01 |
| 卷号 | 482页码:10 |
| ISSN号 | 1387-3806 |
| 关键词 | Mycobacteria Stable isotope dimethyl-labeled proteomic strategy Phosphoproteomics Mass spectrometry Quercetin Caffeic acid |
| DOI | 10.1016/j.ijms.2022.116934 |
| 通讯作者 | Tan, Minjia(mjtan@simm.ac.cn) ; Xu, Jun-Yu(jyxu@simm.ac.cn) |
| 英文摘要 | Tuberculosis is becoming one of the major health concerns worldwide. Although combinatorial therapy with various anti-tuberculosis drugs is a promising treatment option, increasing drug resistance and co -infections is prompting us to develop new medications or explore anti-mycobacterial compounds from bioactive natural products. Previous studies have proved that various natural compounds, especially polyphenols have anti-mycobacterial activities. However, the detailed molecular mechanism remains unknown. In our study, we utilized the quantitative proteomic strategy to explore the dynamic changes at proteome and phosphoproteome levels with the treatment of flavonoid quercetin and non-flavonoid caffeic acid by using the non-pathogenic model organism M. smegmatis as a model. These two poly -phenols are abundant compounds in nature with potential therapeutic effects on infectious diseases. Both polyphenols induced protein changes in the metabolic process of macromolecules and organic compounds. Meantime, quercetin treatment may cause changes in methyltransferase activity and nucleic acid binding. In addition, a reduction in phosphorylation level was observed in several mycobacterial serine/threonine-protein kinases in response to quercetin treatment. In conclusion, our study uncovered the potential antimycobacterial mechanisms of polyphenols, providing new insights into therapeutic strategy in this infectious disease.(c) 2022 Elsevier B.V. All rights reserved. |
| WOS关键词 | NATURAL-PRODUCTS ; TUBERCULOSIS ; FAMILY |
| 资助项目 | National Key R&D Program of China[2021YFA0804700] ; National Key R&D Program of China[2021YFA0804701] ; Natural Science Foundation of China[31901036] ; Natural Science Foundation of China[32071432] ; Shanghai Science and Technology Development Funds[22QA1411100] ; China Postdoctoral Science Foundation[2019T120368] ; Youth Innovation Promotion Association CAS[2021276] ; Sanofi scholarship program |
| WOS研究方向 | Physics ; Spectroscopy |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000862686900003 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302622]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Tan, Minjia; Xu, Jun-Yu |
| 作者单位 | 1.Jiangsu Ocean Univ, Coll Pharm, Jiangsu Key Lab Marine Pharmaceut Cpd Screening, Lianyungang, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Mingya,Liu, Quan,Huang, Yuqi,et al. Comparative proteomic and phosphoproteomic analysis of Mycobacteria treated with flavonoid quercetin and non-flavonoid caffeic acid[J]. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY,2022,482:10. |
| APA | Zhang, Mingya,Liu, Quan,Huang, Yuqi,Wang, Le,Tan, Minjia,&Xu, Jun-Yu.(2022).Comparative proteomic and phosphoproteomic analysis of Mycobacteria treated with flavonoid quercetin and non-flavonoid caffeic acid.INTERNATIONAL JOURNAL OF MASS SPECTROMETRY,482,10. |
| MLA | Zhang, Mingya,et al."Comparative proteomic and phosphoproteomic analysis of Mycobacteria treated with flavonoid quercetin and non-flavonoid caffeic acid".INTERNATIONAL JOURNAL OF MASS SPECTROMETRY 482(2022):10. |
入库方式： OAI收割
来源：上海药物研究所
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