Hypoxia-Activated PEGylated Paclitaxel Prodrug Nanoparticles for Potentiated Chemotherapy
文献类型：期刊论文
| 作者 | Hao, Dengyuan2,3; Meng, Qian3; Jiang, Bowen2,3; Lu, Shaojin2,3; Xiang, Xiujuan2,3; Pei, Qing3; Yu, Haijun1 ; Jing, Xiabin3; Xie, Zhigang2,3
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| 刊名 | ACS NANO
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| 出版日期 | 2022-09-16 |
| 页码 | 10 |
| 关键词 | PEGylation prodrugs self-assembly hypoxia-responsive paclitaxel |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.2c05341 |
| 通讯作者 | Pei, Qing(peiqing@ciac.ac.cn) ; Xie, Zhigang(xiez@ciac.ac.cn) |
| 英文摘要 | Developing controlled drug-release systems is imperative and valuable for increasing the therapeutic index. Herein, we synthesized hypoxia-responsive PEGylated (PEG = poly(ethylene glycol)) paclitaxel prodrugs by utilizing azobenzene (Azo) as a cleavable linker. The as-fabricated prodrugs could self-assemble into stable nanoparticles (PAP NPs) with high drug content ranging from 26 to 44 wt %. The Azo group in PAP NPs could be cleaved at the tumorous hypoxia microenvironment and promoted the release of paclitaxel for exerting cytotoxicity toward cancer cells. In addition, comparative researches revealed that the PAP NPs with the shorter methoxy-PEG chain (molecular weight = 750) possessed enhanced tumor suppression efficacy and alleviated off-target toxicity. Our work demonstrates a promising tactic to develop smart and nanomaterials for disease treatment. |
| WOS关键词 | TUMOR HYPOXIA ; BREAST-CANCER ; DELIVERY ; PEPTIDE ; TAXOL |
| 资助项目 | Natural Science Foundation of Jilin Province[YDZJ202101ZYTS013] ; National Natural Science Foundation of China[51973214] ; Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000861703700001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302628]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Pei, Qing; Xie, Zhigang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Sci & Technol China, Sch Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Jilin 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hao, Dengyuan,Meng, Qian,Jiang, Bowen,et al. Hypoxia-Activated PEGylated Paclitaxel Prodrug Nanoparticles for Potentiated Chemotherapy[J]. ACS NANO,2022:10. |
| APA | Hao, Dengyuan.,Meng, Qian.,Jiang, Bowen.,Lu, Shaojin.,Xiang, Xiujuan.,...&Xie, Zhigang.(2022).Hypoxia-Activated PEGylated Paclitaxel Prodrug Nanoparticles for Potentiated Chemotherapy.ACS NANO,10. |
| MLA | Hao, Dengyuan,et al."Hypoxia-Activated PEGylated Paclitaxel Prodrug Nanoparticles for Potentiated Chemotherapy".ACS NANO (2022):10. |
入库方式： OAI收割
来源：上海药物研究所
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