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Stereochemical insights into neuroprotective alkaloids from the aerial parts of Emilia sonchifolia

文献类型：期刊论文

作者Huang, Ming-Jin3,4,5; Wang, Jun-Chi2; Shen, Shou-Mao1,3; Si, Jian-Yong2; Guo, Yue-Wei3
刊名FITOTERAPIA
出版日期2022-10-01
卷号162页码:5
关键词Emilia sonchifolia Neuroprotective Alkaloid Dibenz[c,e]azepin-5-one Chiral separation
ISSN号0367-326X
DOI10.1016/j.fitote.2022.105267
通讯作者Si, Jian-Yong(jysi@implad.ac.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要A new alkaloid featured with a dibenz[c,e]azepin-5-one scaffold, namely emililactam A (3), together with a known pyrrolidine alkaloid (emilisonchine, 1) and a known flavonoid alkaloid [8-(2 ''-pyrrolidinone-5 ''-yl)-quercetin, 2] were isolated from the aerial parts of Emilia sonchifolia. Compounds 1 and 2 were isolated as racemic forms which were further separated, for the first time, to their corresponding enantiomers [(+)-1/(-)-1 and (+)-2/(-)-2], respectively, by using chiral-phase HPLC. The structure of new compound 3 was elucidated by extensive spectroscopic analysis. In addition, the absolute configurations of optically pure (+)-1/(-)-1 and (+)-2/(-)-2 were determined by the time-dependent density functional theory electronic circular dichroism (TDDFT-ECD) calculations. In an in vitro bioassay, compounds (+)-1, (-)-1, (+/-)-1, and 3 exhibited moderate neuroprotective effects against corticosterone-induced injuries of PC12 cells.
WOS关键词L. DC
资助项目CAMS Innovation Fund for Medical Sciences (CIFMS)[2017-I2M-1-013] ; National Mega-Project for Innovative Drugs[2018ZX09711-001-001-009] ; DrugInnovation Major Project[SIMM2013ZZ-06] ; SKLDR/SIMM Project ; [2012ZX09301-002-001]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000862695700006
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/302637]  
专题新药研究国家重点实验室
通讯作者Si, Jian-Yong; Guo, Yue-Wei
作者单位1.Yancheng Teachers Univ, Sch Pharm, Yancheng 224007, Peoples R China
2.Chinese Acad Med Sci, Inst Med Plant Dev, Peking Union Med Coll, Beijing 100193, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Guizhou Univ, Dendrobium Res Lab, Guiyang 550025, Peoples R China
5.Guizhou Univ, Coll Agr, Guiyang 550025, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Ming-Jin,Wang, Jun-Chi,Shen, Shou-Mao,et al. Stereochemical insights into neuroprotective alkaloids from the aerial parts of Emilia sonchifolia[J]. FITOTERAPIA,2022,162:5.
APA Huang, Ming-Jin,Wang, Jun-Chi,Shen, Shou-Mao,Si, Jian-Yong,&Guo, Yue-Wei.(2022).Stereochemical insights into neuroprotective alkaloids from the aerial parts of Emilia sonchifolia.FITOTERAPIA,162,5.
MLA Huang, Ming-Jin,et al."Stereochemical insights into neuroprotective alkaloids from the aerial parts of Emilia sonchifolia".FITOTERAPIA 162(2022):5.

入库方式： OAI收割

来源：上海药物研究所

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