The progressive application of single-cell RNA sequencing technology in cardiovascular diseases
文献类型：期刊论文
| 作者 | Ke, Yang9,10; Jian-yuan, Huang3,9; Ping, Zhou4; Yue, Wang; Na, Xing8,10; Jian, Yang7; Kai-xuan, Lin5,6; Yi-fan, Sun2; Han-bin, Lin1,8,9; Rong, Li4 |
| 刊名 | BIOMEDICINE & PHARMACOTHERAPY
 |
| 出版日期 | 2022-10-01 |
| 卷号 | 154页码:14 |
| ISSN号 | 0753-3322 |
| 关键词 | Single -cell analysis Cardiovascular Heart diseases Transcriptomics Data analysis |
| DOI | 10.1016/j.biopha.2022.113604 |
| 通讯作者 | Han-bin, Lin(linhanbin@simm.ac.cn) ; Rong, Li(roseli001@sina.com) |
| 英文摘要 | The mortality rate of cardiovascular disease ranks first in the world. Its pathogenesis involves not only internal factors such as immunity, inflammation, metabolic disorders, and self-development but also external factors such as the environment. In the last decade, the emergence of single-cell technology has greatly promoted the development of disease research. Among them, the more mature single-cell RNA sequencing can carry out high -throughput analysis of single cells while studying with single-cell resolution. This technology enables people to characterize the heterogeneity of single cells, identify rare cell types in heart and blood vessels, and construct human heart cell map. With the data analysis of bioinformatics experts, it can also reconstruct the development track of the heart, to construct a map of heart development. Single-cell sequencing plays an important role in analyzing the human physiological structure and disease progression due to its advantages of single-cell reso-lution. The possibility of combining other omics technologies is proposed by summarizing the existing appli-cation examples and advanced technologies like spatial transcriptome. In this review, we summarize the current single-cell sequencing technologies (plate-based and droplet-based) and describe the data analysis process. The latest findings in cardiovascular disease using single-cell RNA sequencing technology are described. Finally, we discussed the shortcomings of single-cell RNA sequencing technology. At the same time, the possibility of the combination of single-cell RNA sequencing and spatial omics technology, and how to apply it to the study of cardiovascular diseases is discussed. |
| WOS关键词 | GENOME-WIDE EXPRESSION ; HEART ; SEQ ; REGENERATION |
| 资助项目 | National Natural Science Foundation of China[81803761] ; National Natural Science Foundation of China[82100391] ; National Natural Science Foundation of China[8210020865] ; High-level new R & D institute of Department of Science and Technology of Guangdong Province[2019B090904008] ; High-level Innovative Research Institute of Department of Science and Technology of Guangdong Province[2021B0909050003] ; High-level Innovative Research Institute of Department of Science and Technology of Guangdong Province[2060302] ; Shandong Provincial Key Research and Development Program[2021CXGC010508] ; Zhongshan Municipal Bureau of Science and Technology[2020B1126] |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| WOS记录号 | WOS:000860644900006 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302640]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Han-bin, Lin; Rong, Li |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.Chinese Acad Med Sci, Inst Med Informat, Beijing 100020, Peoples R China 3.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China 4.Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, 49 Huayuan North Rd, Beijing 100191, Peoples R China 5.Guangzhou Univ Chinese Med, Guangzhou, Peoples R China 6.Guangzhou Univ Chinese Med, Zhongshan Hosp Tradit Chinese Med, Dept Cardiol, Zhongshan Hosp, Zhongshan, Peoples R China 7.China Acad Chinese Med Sci, Natl Resource Ctr Chinese Mat Med, State Key Lab Breeding Base Daodi Herbs, Beijing 100700, Peoples R China 8.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 9.Chinese Acad Sci, Zhongshan Inst Drug Discovery, SIMM, Zhongshan 528400, Guangdong, Peoples R China 10.China Jiliang Univ, Coll Life Sci, Zhejiang Prov Key Lab Biometrol & Inspection & Qua, Hangzhou 310018, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ke, Yang,Jian-yuan, Huang,Ping, Zhou,et al. The progressive application of single-cell RNA sequencing technology in cardiovascular diseases[J]. BIOMEDICINE & PHARMACOTHERAPY,2022,154:14. |
| APA | Ke, Yang.,Jian-yuan, Huang.,Ping, Zhou.,Yue, Wang.,Na, Xing.,...&Rong, Li.(2022).The progressive application of single-cell RNA sequencing technology in cardiovascular diseases.BIOMEDICINE & PHARMACOTHERAPY,154,14. |
| MLA | Ke, Yang,et al."The progressive application of single-cell RNA sequencing technology in cardiovascular diseases".BIOMEDICINE & PHARMACOTHERAPY 154(2022):14. |
入库方式： OAI收割
来源：上海药物研究所
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