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Improving oral bioavailability of water-insoluble idebenone with bioadhesive liposomes

文献类型：期刊论文

作者Qian, Xiandi2,4; Wang, Guanru4; Li, Jie4; Zhang, Xinyue4; Zhang, Minghui3; Yang, Qingmin3; Zhang, Zhiwen4; Li, Yaping1,4
刊名JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
出版日期2022-09-01
卷号75页码:8
ISSN号1773-2247
关键词Idebenone Poorly water-soluble drugs Oral absorption Bioadhesive Liposome
DOI10.1016/j.jddst.2022.103640
通讯作者Zhang, Zhiwen(zwzhang0125@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要The clinical application of water-insoluble idebenone (IDB) is significantly suffering from the poor aqueous solubility in the gastrointestinal (GI) fluids and limited oral bioavailability. Herein, we designed an IDB-loaded bioadhesive liposome based on poly (maleic anhydride-alt-1-octadecene) (PMO) (termed as IBL) to improve the intestinal absorption and oral bioavailability. IBL was nanometer-sized particles with a Z-average diameter of 95.12 nm and IDB exhibited as amorphous or molecular state in the IBL formulation. At 2 h of oral administration, the tissue concentration of IDB in the duodenum, jejunum, and ileum in the IBL treated group was notably improved 2.69-, 3.21- and 3.44- fold over counterpart liposomal formulation of IDB (LI). Moreover, in the IBL treated group, the oral bioavailability of IDB was obviously enhanced 3.79-fold than that in free drug suspension and 2.33-fold when compared to counterpart LI treatment. Therefore, the bioadhesive liposome represents a feasible and elegant strategy to improve the oral absorption of water-insoluble IDB.
WOS关键词DRUG-DELIVERY SYSTEMS ; NANOPARTICLES ; EFFICACY ; ENHANCE ; PHARMACOKINETICS ; METASTASIS ; METABOLISM ; ABSORPTION ; PACLITAXEL ; MECHANISM
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者ELSEVIER
WOS记录号WOS:000863189100001
源URL[http://119.78.100.183/handle/2S10ELR8/302646]  
专题新药研究国家重点实验室
通讯作者Zhang, Zhiwen; Li, Yaping
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
2.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
3.Qilu Pharmaceut Co Ltd, Jinan 250100, Shandong, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Ctr Pharmaceut, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Qian, Xiandi,Wang, Guanru,Li, Jie,et al. Improving oral bioavailability of water-insoluble idebenone with bioadhesive liposomes[J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,2022,75:8.
APA Qian, Xiandi.,Wang, Guanru.,Li, Jie.,Zhang, Xinyue.,Zhang, Minghui.,...&Li, Yaping.(2022).Improving oral bioavailability of water-insoluble idebenone with bioadhesive liposomes.JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,75,8.
MLA Qian, Xiandi,et al."Improving oral bioavailability of water-insoluble idebenone with bioadhesive liposomes".JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 75(2022):8.

入库方式： OAI收割

来源：上海药物研究所

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