Comparative Pharmacokinetic Study of Two Pyrrolizidine Alkaloids Lasiocarpine and Heliotrine in Rats
文献类型：期刊论文
| 作者 | Lin, Feifei1,2 ; Zhao, Lijuan1; Wang, Yingying1; Ye, Yang1,2; Liu, Jia1
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| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2022-09-28 |
| 页码 | 9 |
| 关键词 | Lasiocarpine Heliotrine pyrrolizidine alkaloid pharmacokinetics |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/a-1915-5456 |
| 通讯作者 | Ye, Yang(yye@simm.ac.cn) ; Liu, Jia(jia.liu@simm.ac.cn) |
| 英文摘要 | Lasiocarpine (LAS) and heliotrine (HEL) are two different ester types of toxic pyrrolizidine alkaloids (PAs): open-chain diester and monoester. However, the pharmacokinetics of these two types of PAs in rats have not been reported. In the present study, two LC-MS/MS methods for determining LAS and HEL were established and validated. The methods exhibited good linearity, accuracy, and precision and were then applied to a comparative pharmacokinetic study. After intravenous administration to male rats at 1 mg/kg, the AUC (0-t) values of LAS and HEL were 336 +/- 26 ng/mL x h and 170 +/- 5 ng/mL x h. After oral administration at 10 mg/kg, the AUC (0-t) of LAS was much lower than that of HEL (18.2 +/- 3.8 ng/mL x h vs. 396 +/- 18 ng/mL x h), while the C (max) of LAS was lower than that of HEL (51.7 +/- 22.5 ng/mL x h vs. 320 +/- 26 ng/mL x h). The absolute oral bioavailability of LAS was 0.5%, which was significantly lower than that of HEL (23.3%). The results revealed that the pharmacokinetic behaviors of LAS differed from that of HEL. |
| WOS关键词 | METABOLIC-ACTIVATION ; TOXICITY |
| 资助项目 | National Natural Science Foundation of China[81803610] ; National Natural Science Foundation of China[21920102003] ; Science and Technology Commission of Shanghai Municipality[20430780300] ; Key-Area Research and Development Program of Guangdong Province[2020B0303070002] ; Shanghai Municipal Science and Technology Major Project |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000860857200004 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302664]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Ye, Yang; Liu, Jia |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Feifei,Zhao, Lijuan,Wang, Yingying,et al. Comparative Pharmacokinetic Study of Two Pyrrolizidine Alkaloids Lasiocarpine and Heliotrine in Rats[J]. PLANTA MEDICA,2022:9. |
| APA | Lin, Feifei,Zhao, Lijuan,Wang, Yingying,Ye, Yang,&Liu, Jia.(2022).Comparative Pharmacokinetic Study of Two Pyrrolizidine Alkaloids Lasiocarpine and Heliotrine in Rats.PLANTA MEDICA,9. |
| MLA | Lin, Feifei,et al."Comparative Pharmacokinetic Study of Two Pyrrolizidine Alkaloids Lasiocarpine and Heliotrine in Rats".PLANTA MEDICA (2022):9. |
入库方式： OAI收割
来源：上海药物研究所
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