Dithiocarbazate-copper complex loaded thermosensitive hydrogel for lung cancer therapy via tumor in situ sustained-release
文献类型：期刊论文
| 作者 | Deng, JunGang7; Peng, Chang5,6,7; Hou, LiXia7; Wu, YouRu7; Liu, Wei4; Fang, GuiHua4; Jiang, HaoWen3; Qin, ShanFu2; Yang, Feng1; Huang, GuoJin7 |
| 刊名 | INORGANIC CHEMISTRY FRONTIERS
 |
| 出版日期 | 2022-10-11 |
| 页码 | 12 |
| ISSN号 | 2052-1553 |
| DOI | 10.1039/d2qi01383e |
| 通讯作者 | Huang, GuoJin(sanchuanok@126.com) ; Gou, Yi(1507959392@qq.com) |
| 英文摘要 | The platinum-based antitumor agents currently available are associated with severe side effects. The solution to these side effects Lies in synthesizing non-platinum metal anticancer agents and finding suitable drug delivery strategies. Here we designed and synthesized a series of copper complexes with dithiocarbazate ligands ([Cu-parallel to(L1)Br] 1, [Cu-parallel to(L2)Br] 2, and [(Cu2Cu vertical bar)-Cu-parallel to(L3)(2)(Br)(3)] 3), and assessed their anticancer activities. Of the three complexes, complex(3) showed the highest anticancer activity in vitro. The anticancer mechanism of complex 3 involved mitochondria) respiration inhibition and mitochondria)-mediated apoptosis. The efficacy of complex 3 was improved using thermosensitive hydrogels formed from Pluronic F127 to carry the complex for intratumoral drug delivery. The Pluronic F127 hydrogel containing complex 3 (3@F127) exists in the solution form at low temperature and gels rapidly at body temperature. The in vitro release and in vivo gel formation studies showed that the Pluronic F127 hydrogel could prolong the release of complex 3. An in vivo anticancer assessment showed that 3@F127 could delay A549 tumor xenograft growth more effectively with lower systemic toxicity compared to complex 3 alone. This research provides an effective strategy to improve the anticancer ability of copper complexes. |
| WOS关键词 | DELIVERY ; MITOCHONDRIA ; THIOSEMICARBAZONE ; NANOPARTICLES ; PATHWAYS ; SYSTEM ; TISSUE ; DRUGS ; CELLS ; CU |
| 资助项目 | Natural Science Foundation of Guangxi projects[2020GXNSFBA238003] ; Natural Science Foundation of Guangxi projects[2022GXNSFGA035003] ; National Natural Science Foundation of China[22007023] ; National Natural Science Foundation of China[22267004] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000866987800001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302745]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Huang, GuoJin; Gou, Yi |
| 作者单位 | 1.Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, Guilin 541004, Guangxi, Peoples R China 2.Hechi Univ, Hechi 546300, Guangxi, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Nantong Univ, Sch Pharm, Nantong 226019, Jiangsu, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Chong Zhi Rd, Shanghai 201203, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd, Shanghai 201203, Peoples R China 7.Guilin Med Univ, Lab Resp Dis, Guilin 541001, Guangxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, JunGang,Peng, Chang,Hou, LiXia,et al. Dithiocarbazate-copper complex loaded thermosensitive hydrogel for lung cancer therapy via tumor in situ sustained-release[J]. INORGANIC CHEMISTRY FRONTIERS,2022:12. |
| APA | Deng, JunGang.,Peng, Chang.,Hou, LiXia.,Wu, YouRu.,Liu, Wei.,...&Gou, Yi.(2022).Dithiocarbazate-copper complex loaded thermosensitive hydrogel for lung cancer therapy via tumor in situ sustained-release.INORGANIC CHEMISTRY FRONTIERS,12. |
| MLA | Deng, JunGang,et al."Dithiocarbazate-copper complex loaded thermosensitive hydrogel for lung cancer therapy via tumor in situ sustained-release".INORGANIC CHEMISTRY FRONTIERS (2022):12. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。