Mass spectrometry imaging: new eyes on natural products for drug research and development
文献类型：期刊论文
| 作者 | Hou, Jin-jun2,3 ; Zhang, Zi-jia2,3; Wu, Wen-yong1,3; He, Qing-qing3; Zhang, Teng-qian2,3; Liu, Ya-wen2,3; Wang, Zhao-jun2,3; Gao, Lei2,3; Long, Hua-li2,3; Lei, Min2,3
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2022-10-13 |
| 页码 | 16 |
| 关键词 | natural product mass spectrometry imaging MALDI DESI molecular imaging ion mobility |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-022-00990-8 |
| 通讯作者 | Wu, Wan-ying(wanyingwu@simm.ac.cn) ; Guo, De-an(daguo@simm.ac.cn) |
| 英文摘要 | Natural products (NPs) and their structural analogs represent a major source of novel drug development for disease prevention and treatment. The development of new drugs from NPs includes two crucial aspects. One is the discovery of NPs from medicinal plants/microorganisms, and the other is the evaluation of the NPs in vivo at various physiological and pathological states. The heterogeneous spatial distribution of NPs in medicinal plants/microorganisms or in vivo can provide valuable information for drug development. However, few molecular imaging technologies can detect thousands of compounds simultaneously on a label-free basis. Over the last two decades, mass spectrometry imaging (MSI) methods have progressively improved and diversified, thereby allowing for the development of various applications of NPs in plants/microorganisms and in vivo NP research. Because MSI allows for the spatial mapping of the production and distribution of numerous molecules in situ without labeling, it provides a visualization tool for NP research. Therefore, we have focused this mini-review on summarizing the applications of MSI technology in discovering NPs from medicinal plants and evaluating NPs in preclinical studies from the perspective of new drug research and development (R&D). Additionally, we briefly reviewed the factors that should be carefully considered to obtain the desired MSI results. Finally, the future development of MSI in new drug R&D is proposed. |
| WOS关键词 | ION MOBILITY SPECTROMETRY ; ELECTROSPRAY-IONIZATION ; TISSUE-SECTIONS ; MATRIX ; BRAIN ; QUANTITATION ; METABOLITES ; PROTEINS ; DELIVERY ; HETEROGENEITY |
| 资助项目 | STS (the Science and Technology Service Network Initiative of the Chinese Academy of Sciences) program[KFJ-STS-QYZD-2021-03-003] ; National Natural Science Foundation of China[81530095] ; National Natural Science Foundation of China[81673591] ; National Natural Science Foundation of China[81973455] ; National Natural Science Foundation of China[81973470] ; National Natural Science Foundation of China[82003939] ; National Natural Science Foundation of China[82003915] ; National Key Research and Development Program of China[2018YFC1707900] ; National Key Research and Development Program of China[2018YFC1707001] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000867545400002 |
| 出版者 | NATURE PUBL GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302751]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wu, Wan-ying; Guo, De-an |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210029, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hou, Jin-jun,Zhang, Zi-jia,Wu, Wen-yong,et al. Mass spectrometry imaging: new eyes on natural products for drug research and development[J]. ACTA PHARMACOLOGICA SINICA,2022:16. |
| APA | Hou, Jin-jun.,Zhang, Zi-jia.,Wu, Wen-yong.,He, Qing-qing.,Zhang, Teng-qian.,...&Guo, De-an.(2022).Mass spectrometry imaging: new eyes on natural products for drug research and development.ACTA PHARMACOLOGICA SINICA,16. |
| MLA | Hou, Jin-jun,et al."Mass spectrometry imaging: new eyes on natural products for drug research and development".ACTA PHARMACOLOGICA SINICA (2022):16. |
入库方式： OAI收割
来源：上海药物研究所
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