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Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases

文献类型：期刊论文

作者Ma, Chenhui5,6,7; Han, Li5,6; Zhu, Zheying3,4; Pang, Cheng Heng1,2,7; Pan, Guoyu5,6
刊名BIOCHEMICAL PHARMACOLOGY
出版日期2022-11-01
卷号205页码:13
ISSN号0006-2952
关键词Mineral Iron Ferroptosis Copper Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis
DOI10.1016/j.bcp.2022.115242
通讯作者Zhu, Zheying(Zheying.Zhu@nottingham.ac.uk) ; Pang, Cheng Heng(chengheng.pang@nottingham.edu.cn) ; Pan, Guoyu(gypan@simm.ac.cn)
英文摘要Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease worldwide. Minerals including iron, copper, zinc, and selenium, fulfil an essential role in various biochemical processes. Moreover, the identification of ferroptosis and cuproptosis further underscores the importance of intracellular mineral homeostasis. However, perturbation of minerals has been frequently reported in patients with NAFLD and related diseases. Interestingly, studies have attempted to establish an association between mineral disorders and NAFLD pathological features, including oxidative stress, mitochondrial dysfunction, inflammatory response, and fibrogenesis. In this review, we aim to provide an overview of the current understanding of mineral metabolism (i.e., absorption, utilization, and transport) and mineral interactions in the pathogenesis of NAFLD. More importantly, this review highlights potential therapeutic strategies, challenges, future directions for tar -geting mineral metabolism in the treatment of NAFLD.
WOS关键词HEPATIC COPPER CONCENTRATIONS ; SELENIUM CO-SUPPLEMENTATION ; TRANSFERRIN-BOUND IRON ; METAL TRANSPORTER 1 ; INSULIN-RESISTANCE ; ZINC TRANSPORTERS ; OXIDATIVE STRESS ; MURINE MODEL ; RAT MODEL ; HEPCIDIN
资助项目National Science Foundation of China[81872927] ; Organ Reconstruction and Manufacturing Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16020205] ; University of Nottingham Ningbo China ; Shanghai Institute of Materia Medica, Chinese Academy of Sciences
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:000863519800005
源URL[http://119.78.100.183/handle/2S10ELR8/302754]  
专题中国科学院上海药物研究所
通讯作者Zhu, Zheying; Pang, Cheng Heng; Pan, Guoyu
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Room 1715,501 Haike Rd, Shanghai, Peoples R China
2.Univ Nottingham Ningbo China, Room 332,Sir Peter Mansfield Bldg,199 Taikang East, Ningbo, Peoples R China
3.Univ Nottingham, Room C04 Boots Sci Bldg, Nottingham NG7 2RD, England
4.Univ Nottingham, Sch Pharm, Div Mol Therapeut & Formulat, Univ Pk Campus, Nottingham NG7 2RD, England
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
7.Univ Nottingham Ningbo China, Dept Chem & Environm Engn, Ningbo 315100, Peoples R China
推荐引用方式
GB/T 7714		 Ma, Chenhui,Han, Li,Zhu, Zheying,et al. Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases[J]. BIOCHEMICAL PHARMACOLOGY,2022,205:13.
APA Ma, Chenhui,Han, Li,Zhu, Zheying,Pang, Cheng Heng,&Pan, Guoyu.(2022).Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases.BIOCHEMICAL PHARMACOLOGY,205,13.
MLA Ma, Chenhui,et al."Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases".BIOCHEMICAL PHARMACOLOGY 205(2022):13.

入库方式： OAI收割

来源：上海药物研究所

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