Inhibition of the transcription factor ZNF281 by SUFU to suppress tumor cell migration
文献类型：期刊论文
| 作者 | Deng, Yanran4; Peng, Dezhen4; Xiao, Jing3; Zhao, Yunhe2; Ding, Wenhao2; Yuan, Shengtao4; Sun, Li4; Ding, Jian1,4 ; Zhou, Zizhang2; Zhan, Meixiao3
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| 刊名 | CELL DEATH AND DIFFERENTIATION
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| 出版日期 | 2022-10-11 |
| 页码 | 14 |
| ISSN号 | 1350-9047 |
| DOI | 10.1038/s41418-022-01073-1 |
| 通讯作者 | Ding, Jian(jding@simm.ac.cn) ; Zhou, Zizhang(zhouzz@sdau.edu.cn) ; Zhan, Meixiao(zhanmeixiao1987@163.com) |
| 英文摘要 | Although the Hedgehog (Hh) pathway plays an evolutionarily conserved role from Drosophila to mammals, some divergences also exist. Loss of Sufu, an important component of the Hh pathway, does not lead to an obvious developmental defect in Drosophila. However, in mammals, loss of SUFU results in serious disorder, even various cancers. This divergence suggests that SUFU plays additional roles in mammalian cells, besides regulating the Hh pathway. Here, we identify that the transcription factor ZNF281 is a novel binding partner of SUFU. Intriguingly, the Drosophila genome does not encode any homologs of ZNF281. SUFU is able to suppress ZNF281-induced tumor cell migration and DNA damage repair by inhibiting ZNF281 activity. Mechanistically, SUFU binds ZNF281 to mask the nuclear localization signal of ZNF281, culminating in ZNF281 cytoplasmic retention. In addition, SUFU also hampers the interactions between ZNF281 and promoters of target genes. Finally, we show that SUFU is able to inhibit ZNF281-induced tumor cell migration using an in vivo model. Taken together, these results uncover a Hh-independent mechanism of SUFU exerting the anti-tumor role, in which SUFU suppresses tumor cell migration through antagonizing ZNF281. Therefore, this study provides a possible explanation for the functional divergence of SUFU in mammals and Drosophila. |
| WOS关键词 | DNA-DAMAGE ; HEDGEHOG ; DROSOPHILA ; CI/GLI ; MECHANISMS ; METASTASIS ; ACTIVATION ; MUTATIONS ; POLARITY ; PATHWAY |
| 资助项目 | National Natural Science Foundation of China[31922011] ; National Natural Science Foundation of China[31802012] ; National Natural Science Foundation of China[ZR2021MH137] ; National Key Research and Development Program of China[2017YFA0205200] ; Program for Scientific Research Innovation Team of Young Scholar in Colleges and Universities of Shandong Province[2019KJE009] ; Construction Engineering Special Fund of Taishan Scholars[Ts201712022] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| 出版者 | SPRINGERNATURE |
| WOS记录号 | WOS:000865912600001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302763]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ding, Jian; Zhou, Zizhang; Zhan, Meixiao |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Shandong Agr Univ, Coll Life Sci, State Key Lab Crop Biol, Tai An 271018, Shandong, Peoples R China 3.Zhuhai Peoples Hosp, Ctr Intervent Radiol, Zhuhai Precis Med Ctr, Zhuhai 519000, Peoples R China 4.China Pharmaceut Univ, Jiangsu Key Lab Drug Screening, Nanjing 210009, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Yanran,Peng, Dezhen,Xiao, Jing,et al. Inhibition of the transcription factor ZNF281 by SUFU to suppress tumor cell migration[J]. CELL DEATH AND DIFFERENTIATION,2022:14. |
| APA | Deng, Yanran.,Peng, Dezhen.,Xiao, Jing.,Zhao, Yunhe.,Ding, Wenhao.,...&Zhan, Meixiao.(2022).Inhibition of the transcription factor ZNF281 by SUFU to suppress tumor cell migration.CELL DEATH AND DIFFERENTIATION,14. |
| MLA | Deng, Yanran,et al."Inhibition of the transcription factor ZNF281 by SUFU to suppress tumor cell migration".CELL DEATH AND DIFFERENTIATION (2022):14. |
入库方式： OAI收割
来源：上海药物研究所
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