Differences between the metabolic profiles of decompensated and compensated cirrhosis patients with Hepatitis B virus infections under high-performance liquid chromatography-mass spectrometry
文献类型：期刊论文
| 作者 | Chen, Yu1,2; Xu, Zhiliang3; Kong, Hongwei3; Chen, Nan2; Chen, Jing3; Zhou, Lina3; Wang, Feiling4; Dong, Yuejiao2; Zheng, Shufa2; Chen, Zhenjing2 |
| 刊名 | metabolomics
 |
| 出版日期 | 2012-10-01 |
| 卷号 | 8期号:5页码:845-853 |
| 关键词 | Metabolomics Hepatitis B HPLC-MS Compensated liver cirrhosis Decompensated liver cirrhosis Child-turcotte-pugh scoring |
| 产权排序 | 3,2 |
| 通讯作者 | 孔宏伟 ; lanjuanli |
| 英文摘要 | to improve the grading and staging of liver cirrhosis among patients with hbv infection noninvasively, a high-performance liquid chromatography with mass spectrometry metabolomics method was used to investigate the potential metabolic biomarkers in the serum of patients with different degrees of hepatic cirrhosis. the results demonstrate that lysophosphatidyl choline (lpc) from positive electrospray ionization (esi) mode, and fatty acids and bile acids from negative esi mode play important roles in distinguishing decompensated from compensated cirrhosis. a total of 21 differential metabolites were found from the two groups of patients. lpcs, fatty acids, and taurocholic acid (tca) 3-sulfate decreased in patients with decompensated cirrhosis, whereas other bile acids increased significantly. the levels of tca 3-sulfate, lpc 16:0, and lpc 18:0 were significantly correlated with the stages of the decompensated cirrhosis, and they may serve as potential biomarkers for the stage assessment of liver cirrhosis in patients with hbv infections. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | endocrinology & metabolism |
| 研究领域[WOS] | endocrinology & metabolism |
| 关键词[WOS] | hepatocellular-carcinoma ; liver-cirrhosis ; bile-acids ; biomarkers ; serum ; metabonomics ; disease ; biopsy ; rat |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000309681300009 |
| 公开日期 | 2013-10-11 |
| 源URL | [http://159.226.238.44/handle/321008/117726]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Zhejiang Univ, Sch Med, State Key Lab Diag & Treatment Infect Dis, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China 2.Zhejiang Univ, Coll Med, Affiliated Hosp 1, Ctr Clin Lab, Hangzhou 310003, Zhejiang, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 4.Wenzhou Med Coll, Wenzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yu,Xu, Zhiliang,Kong, Hongwei,et al. Differences between the metabolic profiles of decompensated and compensated cirrhosis patients with Hepatitis B virus infections under high-performance liquid chromatography-mass spectrometry[J]. metabolomics,2012,8(5):845-853. |
| APA | Chen, Yu.,Xu, Zhiliang.,Kong, Hongwei.,Chen, Nan.,Chen, Jing.,...&Li, Lanjuan.(2012).Differences between the metabolic profiles of decompensated and compensated cirrhosis patients with Hepatitis B virus infections under high-performance liquid chromatography-mass spectrometry.metabolomics,8(5),845-853. |
| MLA | Chen, Yu,et al."Differences between the metabolic profiles of decompensated and compensated cirrhosis patients with Hepatitis B virus infections under high-performance liquid chromatography-mass spectrometry".metabolomics 8.5(2012):845-853. |
入库方式： OAI收割
来源：大连化学物理研究所
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