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Responses of Chemosensory Perception to Stimulation of the Human Brain

文献类型：期刊论文

作者Li, Yanyan2,3; Tan, Zheng2,3; Wang, Jing1; Cai, Yufei2,3; Wang, Mengyang1; Zhou, Wen2,3; Wang, Liang2,3
刊名ANNALS OF NEUROLOGY
出版日期2022-10-25
页码9
ISSN号0364-5134
DOI10.1002/ana.26532
通讯作者Wang, Liang(lwang@psych.ac.cn)
英文摘要Objective Significant advances have been made in our understanding of the neural substrates of human chemosensory processing, involving the piriform cortex, insula, and orbitofrontal cortex. However, the important and challenging issues are to localize the brain regions with high anatomic precision that can causally produce chemosensory perception and further delineate the topography of different classifications of chemosensory perception. Methods We quantitatively measured subjective responses of chemosensory perception to intracranial electrical stimulation over the brain in neurosurgical patients (n = 302) with medically refractory epilepsy. Results The chemosensory perceptions including olfaction, gustation, and chemesthesis were elicited in 21 of 302 patients (7%). Chemosensory responses were evoked in 53 (0.2%) of 21,661 stimulated sites. The highest response rate (1.8%) was in the insula (37/2,051 stimulated sites from 15/163 patients). The chemosensory perception emerged predominantly during stimulation of the insula along the central sulcus axis. Notably, there existed a distinct pattern that the anteroventral insula predominately represented orthonasal olfaction, whereas different chemosensory modalities converged in the mid-dorsal insula. Interpretation This study provided a detailed characterization of chemosensory perception across the brain, especially in the insula. These results suggest that the cortex along the banks of the central sulcus of the insula may play a role in producing the supramodal sensation of flavor. It also indicates that dysfunction of the central insula should be considered during the evaluation of chemosensory-related epileptic seizures. ANN NEUROL 2022
收录类别SCI
WOS关键词ORBITOFRONTAL CORTEX ; INSULAR CORTEX ; LOBE ; SEIZURES ; HALLUCINATIONS ; ORTHONASAL ; ACTIVATION ; FLAVOR
资助项目National Science and Technology Innovation 2030 Major Program[2022ZD0205000] ; National Natural Science Foundation of China[32020103009] ; National Natural Science Foundation of China[31500923] ; National Natural Science Foundation of China[31771255] ; Ministry Key Project[GW089000] ; CAS Interdisciplinary Innovation Team[JCTD-2018-07] ; Scientific Foundation of the Institute of Psychology, Chinese Academy of Sciences[E2CX4215CX] ; Sanbo Brain Hospital, Capital Medical University[2021ZZLX02]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000871416200001
出版者WILEY
资助机构National Science and Technology Innovation 2030 Major Program ; National Natural Science Foundation of China ; Ministry Key Project ; CAS Interdisciplinary Innovation Team ; Scientific Foundation of the Institute of Psychology, Chinese Academy of Sciences ; Sanbo Brain Hospital, Capital Medical University
源URL[http://ir.psych.ac.cn/handle/311026/43823]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wang, Liang
作者单位1.Capital Med Univ, Sanbo Brain Hosp, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Li, Yanyan,Tan, Zheng,Wang, Jing,et al. Responses of Chemosensory Perception to Stimulation of the Human Brain[J]. ANNALS OF NEUROLOGY,2022:9.
APA Li, Yanyan.,Tan, Zheng.,Wang, Jing.,Cai, Yufei.,Wang, Mengyang.,...&Wang, Liang.(2022).Responses of Chemosensory Perception to Stimulation of the Human Brain.ANNALS OF NEUROLOGY,9.
MLA Li, Yanyan,et al."Responses of Chemosensory Perception to Stimulation of the Human Brain".ANNALS OF NEUROLOGY (2022):9.

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来源：心理研究所

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