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Design, Synthesis, and Antifungal Activities of Hymexazol Glycosides Based on a Biomimetic Strategy

文献类型：期刊论文

作者Gao, Kun1,2; Qin, Yukun1,2; Wang, Linsong1,2; Li, Xin1,2; Liu, Song1,2; Xing, Ronge1,2; Yu, HuaHua1,2; Chen, Xiaolin1,2; Li, Pengcheng1,2
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2022-07-25
页码16
关键词hymexazol glycosylation antifungal DFT proteomics
ISSN号0021-8561
DOI10.1021/acs.jafc.2c02507
通讯作者Qin, Yukun(ykqin@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
英文摘要Hymexazol (HYM) is irreplaceable for treating soil-borne diseases due to its high efficiency and low cost, as a broadspectrum fungicide. However, when HYM is absorbed by plants, it is rapidly converted into two glycoside metabolites, and the antifungal activities of these glycosides are inferior to that of HYM. Therefore, in this study, to maintain strong antifungal activity in vitro and in vivo, HYM was glycosylated with amino sugars that have diverse biological activities to simulate plant glycosylation. The antifungal experiment proved that glycoside 15 has the highest antifungal activity, and N-acetyl glucosamine and HYM had obvious synergistic effects. According to the structure-activity relationship studies, glycoside 15 had greater numbers of active electron-rich regions and front-line orbital electrons due to the introduction of N-acetyl glucosamine. Moreover, glycoside 15 can significantly promote plant growth and induce an increase in plant defense enzyme activity. Additionally, compared to HYM, the results of electron microscopy and proteomics revealed that glycoside 15 has a unique antifungal mechanism. The promising antifungal activity and interactions with plants mean that glycoside 15 is a potential green fungicide candidate. Furthermore, this research conducted an interesting exploration of the agricultural applications of amino sugars.
资助项目National Key R&D Program of China[2019YFD0900705] ; National Natural Science Foundation of China[42076126] ; Shandong Provincial Natural Science Foundation[ZR2020MD072] ; Shandong Provincial Natural Science Foundation[ZR2021QC006] ; Qingdao Applied Basic Research Project[19-6-2-34-cg] ; Qingdao Science and Technology Demonstration and Guidance Project[20-3-4-22-nsh] ; Science and Technology Plan Project of Shinan District, Qingdao[2020-2-013-QT]
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
语种英语
WOS记录号WOS:000834104900001
出版者AMER CHEMICAL SOC
源URL[http://ir.qdio.ac.cn/handle/337002/179848]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Qin, Yukun; Li, Pengcheng
作者单位1.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Gao, Kun,Qin, Yukun,Wang, Linsong,et al. Design, Synthesis, and Antifungal Activities of Hymexazol Glycosides Based on a Biomimetic Strategy[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2022:16.
APA Gao, Kun.,Qin, Yukun.,Wang, Linsong.,Li, Xin.,Liu, Song.,...&Li, Pengcheng.(2022).Design, Synthesis, and Antifungal Activities of Hymexazol Glycosides Based on a Biomimetic Strategy.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,16.
MLA Gao, Kun,et al."Design, Synthesis, and Antifungal Activities of Hymexazol Glycosides Based on a Biomimetic Strategy".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022):16.

入库方式： OAI收割

来源：海洋研究所

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