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Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents

文献类型：期刊论文

作者Li, Jin2,3; Liu, Bing2,3,4,5; Banaschewski, Tobias6; Bokde, Arun L. W.7,8; Quinlan, Erin Burke9; Desrivieres, Sylvane9; Flor, Herta10,11; Frouin, Vincent12; Garavan, Hugh13,14; Gowland, Penny15
刊名PSYCHOLOGICAL MEDICINE
出版日期2022-04-01
卷号52期号:6页码:1175-1182
ISSN号0033-2917
关键词Cortical volume orbitofrontal cortex polygenic risk score smoking tobacco use
DOI10.1017/S0033291720002962
通讯作者Schumann, Gunter(gunter.schumann@kcl.ac.uk) ; Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
英文摘要Background Tobacco smoking remains one of the leading causes of preventable illness and death and is heritable with complex underpinnings. Converging evidence suggests a contribution of the polygenic risk for smoking to the use of tobacco and other substances. Yet, the underlying brain mechanisms between the genetic risk and tobacco smoking remain poorly understood. Methods Genomic, neuroimaging, and self-report data were acquired from a large cohort of adolescents from the IMAGEN study (a European multicenter study). Polygenic risk scores (PGRS) for smoking were calculated based on a genome-wide association study meta-analysis conducted by the Tobacco and Genetics Consortium. We examined the interrelationships among the genetic risk for smoking initiation, brain structure, and the number of occasions of tobacco use. Results A higher smoking PGRS was significantly associated with both an increased number of occasions of tobacco use and smaller cortical volume of the right orbitofrontal cortex (OFC). Furthermore, reduced cortical volume within this cluster correlated with greater tobacco use. A subsequent path analysis suggested that the cortical volume within this cluster partially mediated the association between the genetic risk for smoking and the number of occasions of tobacco use. Conclusions Our data provide the first evidence for the involvement of the OFC in the relationship between smoking PGRS and tobacco use. Future studies of the molecular mechanisms underlying tobacco smoking should consider the mediation effect of the related neural structure.
WOS关键词VENTROMEDIAL PREFRONTAL CORTEX ; SELF-REPORTED SMOKING ; CIGARETTE-SMOKING ; PRENATAL-EXPOSURE ; DECISION-MAKING ; METAANALYSIS ; NICOTINE ; IMPULSIVENESS ; ASSOCIATION ; VALIDATION
资助项目National Key Basic Research and Development Program (973)[2011CB707800] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB02030300] ; Natural Science Foundation of China[81000582] ; Natural Science Foundation of China[31300934] ; Natural Science Foundation of China[91132301] ; Natural Science Foundation of China[91232718] ; European Union[LSHM-CT-2007-037286] ; Horizon 2020[695313] ; ERANID (Understanding the Interplay between Cultural, Biological, and Subjective Factors in Drug Use Pathways)[PR-ST-041610004] ; BRIDGET (JPND: BRain Imaging, cognition Dementia and next generation GEnomics)[MR/N027558/1] ; Human Brain Project (HBP SGA 2)[785907] ; FP7 project MATRICS[603016] ; Medical Research Council Grant 'c-VEDA' (Consortium on Vulnerability to Externalizing Disorders and Addictions)[MR/N000390/1] ; National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London ; Bundesministeriumfur Bildung und Forschung (BMBF)[01GS08152] ; Bundesministeriumfur Bildung und Forschung (BMBF)[01EV0711] ; Bundesministeriumfur Bildung und Forschung (BMBF)[01EE1406A] ; Bundesministeriumfur Bildung und Forschung (BMBF)[01EE1406B] ; Deutsche Forschungsgemeinschaft (DFG)[SM 80/7-2] ; Deutsche Forschungsgemeinschaft (DFG)[SFB 940] ; Deutsche Forschungsgemeinschaft (DFG)[TRR 265] ; Deutsche Forschungsgemeinschaft (DFG)[NE 1383/14-1] ; Medical Research Foundation ; Medical Research Council[MR/R00465X/1] ; Medical Research Council[MR/S020306/1] ; National Institutes of Health (NIH)[5U54EB020403-05] ; National Institutes of Health (NIH)[1R56AG058854-01] ; ANR[AF12-NEUR0008-01 -WM2NA] ; ANR[ANR-12-SAMA-0004] ; Eranet Neuron[ANR-18-NEUR00002-01] ; Fondation de France[00081242] ; Fondation pour la Recherche Medicale[DPA20140629802] ; Mission Interministerielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA) ; Assistance-Publique-Hopitaux-de-Paris ; INSERM (interface grant) ; Paris Sud University IDEX 2012 ; fondation de l'Avenir[AP-RM-17-013] ; Federation pour la Recherche sur le Cerveau ; National Institutes of Health ; Science Foundation Ireland[16/ERCD/3797] ; U.S.A. (Axon, Testosterone and Mental Health during Adolescence)[RO1 MH085772-01A1] ; NIH Consortium grant - cross-NIH alliance[U54 EB020403]
WOS研究方向Psychology ; Psychiatry
语种英语
出版者CAMBRIDGE UNIV PRESS
WOS记录号WOS:000849361300020
资助机构National Key Basic Research and Development Program (973) ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Natural Science Foundation of China ; European Union ; Horizon 2020 ; ERANID (Understanding the Interplay between Cultural, Biological, and Subjective Factors in Drug Use Pathways) ; BRIDGET (JPND: BRain Imaging, cognition Dementia and next generation GEnomics) ; Human Brain Project (HBP SGA 2) ; FP7 project MATRICS ; Medical Research Council Grant 'c-VEDA' (Consortium on Vulnerability to Externalizing Disorders and Addictions) ; National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London ; Bundesministeriumfur Bildung und Forschung (BMBF) ; Deutsche Forschungsgemeinschaft (DFG) ; Medical Research Foundation ; Medical Research Council ; National Institutes of Health (NIH) ; ANR ; Eranet Neuron ; Fondation de France ; Fondation pour la Recherche Medicale ; Mission Interministerielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA) ; Assistance-Publique-Hopitaux-de-Paris ; INSERM (interface grant) ; Paris Sud University IDEX 2012 ; fondation de l'Avenir ; Federation pour la Recherche sur le Cerveau ; National Institutes of Health ; Science Foundation Ireland ; U.S.A. (Axon, Testosterone and Mental Health during Adolescence) ; NIH Consortium grant - cross-NIH alliance
源URL[http://ir.ia.ac.cn/handle/173211/50017]  
专题自动化研究所_脑网络组研究中心
通讯作者Schumann, Gunter; Jiang, Tianzi
作者单位1.Humboldt Univ, Dept Psychiat & Psychotherapy, PONS Res Grp, Campus Charite Mitte, Berlin, Germany
2.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, 95 East Zhongguancun Rd, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, 95 East Zhongguancun Rd, Beijing 100190, Peoples R China
4.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, 95 East Zhongguancun Rd, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
6.Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, Sq J5, D-68159 Mannheim, Germany
7.Trinity Coll Dublin, Sch Med, Discipline Psychiat, Dublin, Ireland
8.Trinity Coll Dublin, Trinity Coll Inst Neurosci, Dublin, Ireland
9.Kings Coll London, Ctr Populat Neurosci & Precis Med PONS, SGDP Ctr, Inst Psychiat Psychol & Neurosci, London, England
10.Heidelberg Univ, Med Fac Mannheim, Inst Cognit & Clin Neurosci, Cent Inst Mental Hlth, Sq J5, Mannheim, Germany
推荐引用方式
GB/T 7714		 Li, Jin,Liu, Bing,Banaschewski, Tobias,et al. Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents[J]. PSYCHOLOGICAL MEDICINE,2022,52(6):1175-1182.
APA Li, Jin.,Liu, Bing.,Banaschewski, Tobias.,Bokde, Arun L. W..,Quinlan, Erin Burke.,...&Jiang, Tianzi.(2022).Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents.PSYCHOLOGICAL MEDICINE,52(6),1175-1182.
MLA Li, Jin,et al."Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents".PSYCHOLOGICAL MEDICINE 52.6(2022):1175-1182.

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来源：自动化研究所

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