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The development of cortical functional hierarchy is associated with the molecular organization of prenatal/postnatal periods

文献类型：期刊论文

作者Zhao, Yuxin3,4; Wang, Meng3,4; Hu, Ke3,4; Wang, Qi3,4; Lou, Jing5; Fan, Lingzhong1,3,4; Liu, Bing2,5
刊名CEREBRAL CORTEX
出版日期2022-09-07
页码14
关键词cortical development fMRI gene expression postnatal prenatal
ISSN号1047-3211
DOI10.1093/cercor/bhac340
通讯作者Liu, Bing(bing.liu@bnu.edu.cn)
英文摘要The human cerebral cortex conforms to specific functional hierarchies facilitating information processing and higher-order cognition. Prior studies in adults have unveiled a dominant functional hierarchy spanning from sensorimotor regions to transmodal regions, which is also present in younger cohorts. However, how the functional hierarchy develops and the underlying molecular mechanisms remain to be investigated. Here, we set out to investigate the developmental patterns of the functional hierarchy for preschool children (#scans = 141, age = 2.41-6.90 years) using a parsimonious general linear model and the underlying biological mechanisms by combining the neuroimaging developmental pattern with two separate transcriptomic datasets (i.e. Allen Human Brain Atlas and BrainSpan Atlas). Our results indicated that transmodal regions were further segregated from sensorimotor regions and that such changes were potentially driven by two gene clusters with distinct enrichment profiles, namely prenatal gene cluster and postnatal gene cluster. Additionally, we found similar developmental profiles manifested in subsequent developmental periods by conducting identical analyses on the Human Connectome Projects in Development (#scans = 638, age = 5.58-21.92 years) and Philadelphia Neurodevelopment Cohort datasets (#scans = 795, age = 8-21 years), driven by concordant two gene clusters. Together, these findings illuminate a comprehensive developmental principle of the functional hierarchy and the underpinning molecular factors, and thus may shed light on the potential pathobiology of neurodevelopmental disorders.
WOS关键词DEFAULT-MODE NETWORK ; GENETIC-CONTROL ; CONNECTIVITY ; CONNECTOME ; EXPRESSION ; DYNAMICS ; PATTERNS ; DISRUPTION ; EMERGENCE
资助项目National Natural Science Foun-dation of China[81771451] ; Startup Funds of Beijing Normal University
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000850608200001
出版者OXFORD UNIV PRESS INC
资助机构National Natural Science Foun-dation of China ; Startup Funds of Beijing Normal University
源URL[http://ir.ia.ac.cn/handle/173211/50038]  
专题自动化研究所_脑网络组研究中心
通讯作者Liu, Bing
作者单位1.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China
2.Chinese Inst Brain Res, Beijing 102206, Peoples R China
3.Chinese Acad Sci, Brainnetome Ctr & Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China
5.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Yuxin,Wang, Meng,Hu, Ke,et al. The development of cortical functional hierarchy is associated with the molecular organization of prenatal/postnatal periods[J]. CEREBRAL CORTEX,2022:14.
APA Zhao, Yuxin.,Wang, Meng.,Hu, Ke.,Wang, Qi.,Lou, Jing.,...&Liu, Bing.(2022).The development of cortical functional hierarchy is associated with the molecular organization of prenatal/postnatal periods.CEREBRAL CORTEX,14.
MLA Zhao, Yuxin,et al."The development of cortical functional hierarchy is associated with the molecular organization of prenatal/postnatal periods".CEREBRAL CORTEX (2022):14.

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来源：自动化研究所

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