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X-box Binding Protein 1: An Adaptor in the Pathogenesis of Atherosclerosis

文献类型：期刊论文

作者Wang, Tao5,6; Zhou, Jia7; Zhang, Xiao5,6; Wu, Yujie8; Jin, Kehan7; Wane, Yilin3,4; Xu, Ran5,6; Yang, Ge1,8; Li, Wenjing1,8; Jiao, Liqun2,5,6
刊名AGING AND DISEASE
出版日期2022-08-25
页码20
ISSN号2152-5250
关键词Endoplasmic Reticulum Stress Unfolded Protein Response XBP1 IRE1? Atherosclerosis
DOI10.14336/AD.2022.0824
通讯作者Yang, Ge(ge.yang@ia.ac.cn) ; Li, Wenjing(wenjing.li@ia.ac.cn) ; Jiao, Liqun(liqunjiao@sina.cn)
英文摘要Atherosclerosis (AS), the formation of fibrofatty lesions in the vessel wall, is the primary cause of heart disease and stroke and is closely associated with aging. Disrupted metabolic homeostasis is a primary feature of AS and leads to endoplasmic reticulum (ER) stress, which is an abnormal accumulation of unfolded proteins. By orchestrating signaling cascades of the unfolded protein response (UPR), ER stress functions as a double-edged sword in AS, where adaptive UPR triggers synthetic metabolic processes to restore homeostasis, whereas the maladaptive response programs the cell to the apoptotic pathway. However, little is known regarding their precise coordination. Herein, an advanced understanding of the role of UPR in the pathological process of AS is reviewed. In particular, we focused on a critical mediator of the UPR, X-box binding protein 1 (XBP1), and its important role in balancing adaptive and maladaptive responses. The XBP1 mRNA is processed from the unspliced isoform (XBP1u) to the spliced isoform of XBP1 (XBP1s). Compared with XBP1u, XBP1s predominantly functions downstream of inositol-requiring enzyme-1?? (IRE1??) and transcript genes involved in protein quality control, inflammation, lipid metabolism, carbohydrate metabolism, and calcification, which are critical for the pathogenesis of AS. Thus, the IRE1??/XBP1 axis is a promising pharmaceutical candidate against AS.
WOS关键词ENDOPLASMIC-RETICULUM STRESS ; SMOOTH-MUSCLE-CELLS ; ENDOTHELIAL GROWTH-FACTOR ; RESPONSE ACTIVATOR PXBP1(S) ; TRANSCRIPTION FACTOR 4 ; ER STRESS ; MESSENGER-RNA ; IRE1-ALPHA-XBP1 PATHWAY ; MYOCARDIAL-INFARCTION ; GLUCOSE-HOMEOSTASIS
资助项目National Natural Science Foundation of China[821 71303] ; Beijing Municipal Science & Technology Commission[5202022]
WOS研究方向Geriatrics & Gerontology
语种英语
出版者INT SOC AGING & DISEASE
WOS记录号WOS:000848057600001
资助机构National Natural Science Foundation of China ; Beijing Municipal Science & Technology Commission
源URL[http://ir.ia.ac.cn/handle/173211/50050]  
专题模式识别国家重点实验室_计算生物学与机器智能
通讯作者Yang, Ge; Li, Wenjing; Jiao, Liqun
作者单位1.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China
2.Capital Med Univ, Xuanwu Hosp, Dept Intervent Radiol, Beijing, Peoples R China
3.Capital Med Univ, Xuanwu Hosp, Inst Cerebrovasc Dis Res, Beijing, Peoples R China
4.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
5.China Int Neurosci Inst China INI, Beijing, Peoples R China
6.Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
7.Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Beijing, Peoples R China
8.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Lab Computat Biol & Machine Intelligence, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Tao,Zhou, Jia,Zhang, Xiao,et al. X-box Binding Protein 1: An Adaptor in the Pathogenesis of Atherosclerosis[J]. AGING AND DISEASE,2022:20.
APA Wang, Tao.,Zhou, Jia.,Zhang, Xiao.,Wu, Yujie.,Jin, Kehan.,...&Jiao, Liqun.(2022).X-box Binding Protein 1: An Adaptor in the Pathogenesis of Atherosclerosis.AGING AND DISEASE,20.
MLA Wang, Tao,et al."X-box Binding Protein 1: An Adaptor in the Pathogenesis of Atherosclerosis".AGING AND DISEASE (2022):20.

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来源：自动化研究所

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