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Colourful fluorescence-based carbon dots for tumour imaging-guided nanosurgery

文献类型：期刊论文

作者Shang, Wenting4; Xia, Xueer2; Lu, Ningning4; Gao, Pengli1; Peng, Li4; Liu, Yu1; Deng, Han4; Jiang, Jingying1,7; Li, Zhou2,6; Liu, Jianhua3,5
刊名NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
出版日期2022-09-01
卷号45页码:11
关键词Carbon dots Fluorescent probe Multicolour cancer therapy Nano-theranostic
ISSN号1549-9634
DOI10.1016/j.nano.2022.102583
通讯作者Jiang, Jingying(jingyingjiang@buaa.edu.cn) ; Li, Zhou(gzlizhou@smu.edu.cn) ; Liu, Jianhua(liujianh80@126.com)
英文摘要Fluorescent-intraoperative navigation is a visual technique that allows surgeons to accurately distinguish malignant and normal tissues during surgery. It has the advantages of immediacy, high resolution, and high specificity. However, a single fluorescent source cannot provide sufficient surgical information. Multicolour carbon dots (CDs) are more suitable since they provide outstanding water solubility, photo -stability, and multicolour-fluorescence imaging. Here, we prepared an optical probe with CD-based multicolour-fluorescence imaging via a hydrothermal method. CDs can be endocytosed by tumour cells, and after intravenous injection, they can effectively accumulate at the tumour site. In a pancreatic cancer mouse model, we demonstrated the multicolour-fluorescence imaging capabilities of CDs, which aided the accurate resection of tumours under fluorescent-intraoperative navigation. Stereoscopic fluorescence microscopy imaging and H&E staining proved that the removed tissue belonged to the pancreatic tumour. This study emphasizes the potential of CDs for fluorescence-guided intraoperative resection and expands the application of CDs in biological fields.(c) 2022 Published by Elsevier Inc.
WOS关键词ACID
资助项目National Natural Science Foundation of China[81971680] ; National Natural Science Foundation of China[81971662] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81930053] ; Natural Science Foundation of Beijing City[7202105] ; Research Start-up Funds for National Natural Science Foundation of China[8200110771] ; Research Start-up Funds for National Natural Science Foundation of China[8190110562]
WOS研究方向Science & Technology - Other Topics ; Research & Experimental Medicine
语种英语
WOS记录号WOS:000853225100001
出版者ELSEVIER
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Beijing City ; Research Start-up Funds for National Natural Science Foundation of China
源URL[http://ir.ia.ac.cn/handle/173211/50086]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Jiang, Jingying; Li, Zhou; Liu, Jianhua
作者单位1.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med & Engn, Beijing 100191, Peoples R China
2.Southern Med Univ, Zhujiang Hosp, Gen Surg Ctr, Dept Gastrointestinal Surg, Guangzhou 510000, Peoples R China
3.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Oncol, 123 Huifu Rd West, Guangzhou 510180, Peoples R China
4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging,State Key Lab Managem, Beijing 100190, Peoples R China
5.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Canc Ctr, Dept Oncol, Guangzhou 510000, Peoples R China
6.Southern Med Univ, Zhujiang Hosp, Gen Surg Ctr, Dept Gastrointestinal Surg, 253 Gongye Middle Ave, Guangzhou 510280, Peoples R China
7.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med & Engn, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Shang, Wenting,Xia, Xueer,Lu, Ningning,et al. Colourful fluorescence-based carbon dots for tumour imaging-guided nanosurgery[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2022,45:11.
APA Shang, Wenting.,Xia, Xueer.,Lu, Ningning.,Gao, Pengli.,Peng, Li.,...&Liu, Jianhua.(2022).Colourful fluorescence-based carbon dots for tumour imaging-guided nanosurgery.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,45,11.
MLA Shang, Wenting,et al."Colourful fluorescence-based carbon dots for tumour imaging-guided nanosurgery".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 45(2022):11.

入库方式： OAI收割

来源：自动化研究所

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