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One-year outcomes of polymer-free amphilimus-eluting stents versus durable polymer zotarolimus-eluting stents in patients with diabetes mellitus: a meta-analysis

文献类型：期刊论文

作者Wang,Hong3; Xie,Xiaoya4; Zu,Quannan1; Lu,Ming1; Chen,Rongfa2; Yang,Zhiren2; Gao,Yongqiang3
刊名Cardiovascular Diabetology
出版日期2022-10-28
卷号21期号:1页码:10
关键词Diabetes mellitus Polymer-free Amphilimus-eluting stents Durable polymer zotarolimus-eluting stents Percutaneous coronary intervention Cardiovascular outcomes Target lesion failure Major adverse cardiac events Stent thrombosis
DOI10.1186/s12933-022-01673-8
通讯作者Wang,Hong(iriswh2014@163.com)
英文摘要AbstractBackgroundDiabetes mellitus (DM) and cardiovascular diseases often co-exist. Today, percutaneous coronary intervention (PCI) is the preferred revascularization procedure for majority of patients with coronary artery disease. Polymer-free amphilimus-eluting stents (AES) represent a novel elution technology in the current era of drug-eluting stents. In this analysis, we aimed to systematically compare the cardiovascular outcomes which are associated with polymer-free amphilimus-eluting stents (AES) versus the durable polymer zotarolimus-eluting stents (ZES) for the treatment of patients with DM.MethodsHttp://www.ClinicalTrials.gov, EMBASE, Web of Science, MEDLINE, Cochrane database and Google Scholar were searched for publications comparing polymer-free AES versus durable polymer ZES in patients with DM. Selective cardiovascular outcomes were assessed. Statistical analysis was carried out by the latest version of the RevMan software. Risk ratio (RR) with 95% confidence interval (CI) was used to represent the data analysis.ResultsFour studies with a total number of 1795 participants with DM whereby 912 patients were assigned to be revascularized by the polymer-free AES and 883 patients were assigned to be revascularized by the durable polymer ZES were included in this analysis. In patients with DM, at one year, polymer-free AES were associated with significantly lower risk of major adverse cardiac events (MACEs) (RR: 0.69, 95% CI: 0.54–0.88; P?=?0.002) and target lesion failure (TLF) (RR: 0.66, 95% CI: 0.48–0.91; P?=?0.01) compared to durable polymer ZES. However, there was no significant change in all-cause mortality (RR: 0.79, 95% CI: 0.51–1.22; P?=?0.28), cardiac death and the other cardiovascular outcomes. Similar risk of total stent thrombosis (RR: 1.13, 95% CI: 0.60–2.13; P?=?0.70), including definite stent thrombosis (RR: 1.12, 95% CI: 0.38–3.31; P?=?0.84), probable stent thrombosis (RR: 0.87, 95% CI: 0.37–2.09; P?=?0.76), possible stent thrombosis (RR: 1.19, 95% CI: 0.50–2.87; P?=?0.69) and late stent thrombosis (RR: 1.00, 95% CI: 0.17–5.72; P?=?1.00) as between polymer-free AES and durable polymer ZES in patients with DM.ConclusionsAt 1?year follow-up, polymer-free AES were associated with significantly lower MACEs and TLF compared to durable polymer ZES in these patients with DM, without any increase in mortality, stent thrombosis and other cardiovascular outcomes. However, this analysis is only based on a follow-up time period of one year, therefore, future research should focus on the long term follow-up time period.
WOS关键词CLINICAL-OUTCOMES ; DISEASE ; EVEROLIMUS
资助项目Guangxi Key Research and Development Program ; Guangxi Medical and Health Appropriate Technology Development and Promotion Application Project[S2017077] ; Guangxi Nanning Qingxiu District Science and Technology Development Project[2014S06]
WOS研究方向Cardiovascular System & Cardiology ; Endocrinology & Metabolism
语种英语
出版者BioMed Central
WOS记录号BMC:10.1186/S12933-022-01673-8
资助机构Guangxi Key Research and Development Program ; Guangxi Medical and Health Appropriate Technology Development and Promotion Application Project ; Guangxi Nanning Qingxiu District Science and Technology Development Project
源URL[http://ir.ia.ac.cn/handle/173211/50104]  
专题自动化研究所_复杂系统管理与控制国家重点实验室_互联网大数据与安全信息学研究中心
通讯作者Wang,Hong
作者单位1.Tianjin University; College of Management and Economics
2.Chinese Academy of Sciences; The State Key Laboratory Management and Control for Complex Systems, Institute of Automation
3.The People’s Hospital of Guangxi Zhuang Autonomous Region; Department of Cardiology
4.Macau University of Science and Technology
推荐引用方式
GB/T 7714		 Wang,Hong,Xie,Xiaoya,Zu,Quannan,et al. One-year outcomes of polymer-free amphilimus-eluting stents versus durable polymer zotarolimus-eluting stents in patients with diabetes mellitus: a meta-analysis[J]. Cardiovascular Diabetology,2022,21(1):10.
APA Wang,Hong.,Xie,Xiaoya.,Zu,Quannan.,Lu,Ming.,Chen,Rongfa.,...&Gao,Yongqiang.(2022).One-year outcomes of polymer-free amphilimus-eluting stents versus durable polymer zotarolimus-eluting stents in patients with diabetes mellitus: a meta-analysis.Cardiovascular Diabetology,21(1),10.
MLA Wang,Hong,et al."One-year outcomes of polymer-free amphilimus-eluting stents versus durable polymer zotarolimus-eluting stents in patients with diabetes mellitus: a meta-analysis".Cardiovascular Diabetology 21.1(2022):10.

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来源：自动化研究所

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