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Anisotropic hydrogel fabricated by controlled diffusion as a bio-scaffold for the regeneration of cartilage injury

文献类型：期刊论文

作者Yu, Xiaotian2,3,4; Deng, Zhantao3; Li, Han2,3; Ma, Yuanchen3; Ma, Xibo1,4; Zheng, Qiujian3,5
刊名RSC ADVANCES
出版日期2022-09-28
卷号12期号:43页码:28254-28263
DOI10.1039/d2ra05141a
通讯作者Zheng, Qiujian(zhengqiujian@gdph.org.cn)
英文摘要Controlled fabrication of anisotropic materials has become a hotspot in materials science, particularly biomaterials, since the next generation of tissue engineering is based on the application of heterogeneous structures that can simulate the original biological complexity of the body. The current fabrication method of producing anisotropic materials involves expensive and highly specialized equipment, and not every conventional method can be applied to preparing anisotropic materials for corresponding tissue engineering. Anisotropic materials can be easily applied to a problem in tissue engineering: cartilage injury repairing. The articular cartilage consists of four spatially distinct regions: superficial, transitional, deep, and calcified. Each region has a specific extracellular matrix composition, mechanical properties, and cellular organization; this calls for the application of an anisotropic hydrogel. Controlled diffusion, under the assistance of buoyancy, has been considered a generalized method to prepare materials using a gradient. The diffusion of two solutions can be controlled through the difference in their densities. In addition to providing anisotropy, this method realizes the in situ formation of an anisotropic hydrogel, and simplifies the preparation process, freeing it from the need for expensive equipment such as 3D printing and microfluidics. Herein, an anisotropic hydrogel based on a decellularized extracellular matrix is fabricated and characterized. The as-prepared scaffold possessed specific chemical composition, physical properties, and physiological factor gradient. In vitro experiments ensured its biocompatibility and biological effectiveness; further in vivo experiments confirmed its application in the effective regeneration of cartilage injury.
WOS关键词RAT MENISCUS ; MATRIX ; CELLS ; TISSUES
资助项目Natural Science Foundation of Guangdong Province[2022A1515011306] ; Natural Science Foundation of Guangdong Province[2020A1515010268] ; Natural Science Foundation of Guangdong Province[2021A1515011008] ; Outstanding Young Talents Foundation of Guangdong Provincial People's Hospital[KJ012019091] ; Program of Science and Technology of Guangzhou[202103020166] ; Program of Science and Technology of Guangzhou[201904010424] ; Program of Science and Technology of Guangzhou[202102020924] ; Program of Science and Technology of Guangzhou[202201011229] ; NSFC Incubation Project of Guangdong Provincial People's Hospital[KY0120220031] ; Fundamental Research Funds for the Central Universities[2020ZYGXZR010]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000864396900001
出版者ROYAL SOC CHEMISTRY
资助机构Natural Science Foundation of Guangdong Province ; Outstanding Young Talents Foundation of Guangdong Provincial People's Hospital ; Program of Science and Technology of Guangzhou ; NSFC Incubation Project of Guangdong Provincial People's Hospital ; Fundamental Research Funds for the Central Universities
源URL[http://ir.ia.ac.cn/handle/173211/50317]  
专题自动化研究所_模式识别国家重点实验室_生物识别与安全技术研究中心
通讯作者Zheng, Qiujian
作者单位1.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China
2.Guangdong Cardiovasc Inst, Guangzhou, Guangdong, Peoples R China
3.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Orthoped, Guangzhou, Peoples R China
4.Chinese Acad Sci, Inst Automat, CBSR&NLPR, Beijing, Peoples R China
5.Southern Med Univ, Sch Clin Med 2, Guangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Yu, Xiaotian,Deng, Zhantao,Li, Han,et al. Anisotropic hydrogel fabricated by controlled diffusion as a bio-scaffold for the regeneration of cartilage injury[J]. RSC ADVANCES,2022,12(43):28254-28263.
APA Yu, Xiaotian,Deng, Zhantao,Li, Han,Ma, Yuanchen,Ma, Xibo,&Zheng, Qiujian.(2022).Anisotropic hydrogel fabricated by controlled diffusion as a bio-scaffold for the regeneration of cartilage injury.RSC ADVANCES,12(43),28254-28263.
MLA Yu, Xiaotian,et al."Anisotropic hydrogel fabricated by controlled diffusion as a bio-scaffold for the regeneration of cartilage injury".RSC ADVANCES 12.43(2022):28254-28263.

入库方式： OAI收割

来源：自动化研究所

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