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DH-Mammo PET: a dual-head positron emission mammography system for breast imaging

文献类型：期刊论文

作者Shi, Yu5,6,7,8; Wang, Yirong4; Zhou, Jianwei5,6,7,8; Zhu, Yuzhen3; Lyu, Xudong3; Hui, Hui1,2; Wen, Bo5,6,7,8; Liu, Yanyun5,6,7,8; Li, Lei5,6,7,8; Li, Juntao5,6,7,8
刊名PHYSICS IN MEDICINE AND BIOLOGY
出版日期2022-10-21
卷号67期号:20页码:21
ISSN号0031-9155
关键词performance evaluation mammography dual-head PET system PET-optical
DOI10.1088/1361-6560/ac934c
通讯作者Meng, Fanzhen(mengfz0316@xidian.edu.cn) ; Kang, Fei(fmmukf@qq.com) ; Zhu, Shouping(spzhu@xidian.edu.cn)
英文摘要Objective. To develop a simultaneous positron emission tomography-Optical (OPET) breast imaging dual-head PET subsystem, called DH-Mammo PET, for accurate, early diagnosis and efficacy assessment of breast cancer with high resolution and sensitivity. Approach. We developed a breast-dedicated PET based on LYSO crystal, silicon photomultiplier array and multi-voltage threshold sampling technique. It consists of two detector heads, each with a detection area of 216 mm x 145.5 mm. The distance between the detector heads is fixed at 120 mm. In order to extract coincidences and correct data, GPU-based software coincidence processing, random, scatter, normalization, gap-filling and attenuation corrections were applied in turn. The images were reconstructed using maximum likelihood expectation maximization with depth of interaction (DOI) modeling. The performance of DH-Mammo PET was evaluated referring to NEMA NU 4-2008, NU 2-2007 and Chinese industry recommended standard YY/T 1835-2022. Besides, several clinical patient images of DH-Mammo PET were compared with those of a whole-body PET/CT. Main results. The energy resolution was 14.5%, and time resolution was < 1.31 ns. Indicated by the Na-22 point source imaging, its spatial resolution was 2.60 mm (5.40 mm), 1.00 mm (1.04 mm), and 0.96 mm (0.93 mm) in the X, Y and Z directions, respectively, using the system response matrix with (without) DOI modeling. Indicated by the Derenzo phantom imaging, the spatial resolution was similar to 3.0 mm, <1.2 mm, and X, Y and Z directions. The system sensitivity was 6.87%, 4.89% and 3.37% with an energy window of 100-800, 250-750 and 350-650 keV, respectively. The scatter fraction was 26.43%, and the peak NECR was 162.6 kcps at 24.1 MBq for the modified rat-like phantom. As for the recovery coefficients, they ranged from 0.15 to 1.04 for rods between 1 and 5 mm obtained with a NEMA image quality phantom. The spill-over ratio for the air-filled and water-filled chamber was 0.05 and 0.11, respectively. DH-Mammo PET can provide more image details in clinical experiments and fulfil a fast scan with 60-120 s acquisition time. Significance. Good spatial resolution and high sensitivity of DH-Mammo PET would enable fast and accurate PET imaging of the breast. Besides, combining the DH-Mammo PET with the diffuse optical tomography would make full use of tumor metabolic imaging and tissue endogenous optical imaging, which would improve the accuracy of early clinical diagnosis of small lesions of breast cancers.
WOS关键词WHOLE-BODY PET ; PERFORMANCE EVALUATION ; SCANNER ; RECONSTRUCTION ; CANCER ; ACCURACY ; NORMALIZATION ; RESOLUTION ; DESIGN
资助项目National Key Research and Development Program of China[2016YFC0103800] ; National Natural Science Foundation of China[61901339] ; National Natural Science Foundation of China[62071362] ; Natural Science Foundation of Shaanxi Province[2021SF-169] ; Natural Science Foundation of Shaanxi Province[2021SF-131] ; Natural Science Foundation of Hebei Province[H2022206124] ; Fundamental Research Funds for the Central Universities[JB211209] ; CAS Youth Innovation Promotion Association[2018167] ; CAS Key Technology Talent Program
WOS研究方向Engineering ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
出版者IOP Publishing Ltd
WOS记录号WOS:000864901500001
资助机构National Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Shaanxi Province ; Natural Science Foundation of Hebei Province ; Fundamental Research Funds for the Central Universities ; CAS Youth Innovation Promotion Association ; CAS Key Technology Talent Program
源URL[http://ir.ia.ac.cn/handle/173211/50337]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Meng, Fanzhen; Kang, Fei; Zhu, Shouping
作者单位1.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
2.Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
3.Raycan Technol Co Ltd Suzhou, Suzhou 215163, Jiangsu, Peoples R China
4.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Shaanxi, Peoples R China
5.Xidian Univ, Sch Life Sci & Technol, Xian Key Lab Intelligent Sensing & Regulat Trans, Xian 710126, Shaanxi, Peoples R China
6.Xidian Univ, Sch Life Sci & Technol, Int Joint Res Ctr Adv Med Imaging & Intelligent D, Xian 710126, Shaanxi, Peoples R China
7.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710126, Shaanxi, Peoples R China
8.Xidian Univ, Sch Life Sci & Technol, Xian 710126, Shaanxi, Peoples R China
9.Hebei Med Univ, Sch Med Imaging, Shijiazhuang 050017, Hebei, Peoples R China
推荐引用方式
GB/T 7714		 Shi, Yu,Wang, Yirong,Zhou, Jianwei,et al. DH-Mammo PET: a dual-head positron emission mammography system for breast imaging[J]. PHYSICS IN MEDICINE AND BIOLOGY,2022,67(20):21.
APA Shi, Yu.,Wang, Yirong.,Zhou, Jianwei.,Zhu, Yuzhen.,Lyu, Xudong.,...&Zhu, Shouping.(2022).DH-Mammo PET: a dual-head positron emission mammography system for breast imaging.PHYSICS IN MEDICINE AND BIOLOGY,67(20),21.
MLA Shi, Yu,et al."DH-Mammo PET: a dual-head positron emission mammography system for breast imaging".PHYSICS IN MEDICINE AND BIOLOGY 67.20(2022):21.

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来源：自动化研究所

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