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Network localization of transient global amnesia beyond the hippocampus

文献类型：期刊论文

作者Wang, Tao3,4; Xu, Yicheng1; Li, Deying2,8; Tu, Wenjun7; Li, Yanan3; Miao, Shuai3,4; Li, Jilai1; Wang, Peifu1; Zhao, Fei6; Fan, Lingzhong2,5,8
刊名NEUROLOGICAL SCIENCES
出版日期2022-10-12
页码9
ISSN号1590-1874
关键词Transient global amnesia DMN Lesion network mapping
DOI10.1007/s10072-022-06439-4
通讯作者Fan, Lingzhong(lingzhong.fan@ia.ac.can) ; Yu, Shengyuan(yusy1963@126.com)
英文摘要Background Transient global amnesia is common in the older adult, but the cause and mechanism remain unclear. Focal brain lesions allow for causal links between the lesion location and resulting symptoms, and we based on the reported TGA-causing lesions and used lesion network mapping to explore the causal neuroanatomical substrate of TGA. Methods Fifty-one cases of transient global amnesias with DWI lesions from the literature were identified, and clinical data were extracted and analyzed. Next, we mapped each lesion volume onto a reference brain and computed the network of regions functionally connected to each lesion location using a large normative connectome dataset. Results Lesions primarily occurred in the hippocampus, and in addition to the hippocampus, there are also other locations of TGA-causing lesions such as the cingulate gyrus, anterior thalamic nucleus (ATN), putamen, caudate nucleus, corpus callosum, fornix. More than 90% of TGA-causing lesions inside the hippocampus were functionally connected with the default mode network (DMN). Conclusion Structural abnormality in the hippocampus was the most consistently reported in TGA, and besides the hippocampus, lesions occurring at several other brain locations also could cause TGA. The DMN may also be involved in the pathophysiology of TGA. According to the clinical and neuroimaging characteristics, TGA may be a syndrome with multiple causes and cannot be treated simply as a subtype of TIA.
WOS关键词BASAL GANGLIA ; CONNECTIVITY ; ALZHEIMERS ; SYMPTOMS ; CORTEX ; RISK
WOS研究方向Neurosciences & Neurology
语种英语
出版者SPRINGER-VERLAG ITALIA SRL
WOS记录号WOS:000866303100001
源URL[http://ir.ia.ac.cn/handle/173211/50346]  
专题自动化研究所_脑网络组研究中心
通讯作者Fan, Lingzhong; Yu, Shengyuan
作者单位1.Aerosp Ctr Hosp, Dept Neurol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Med Sch Chinese PLA, Beijing 100853, Peoples R China
4.Chinese Peoples Liberat Army Gen Hosp, Dept Neurol, Beijing 100853, Peoples R China
5.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China
6.Aerosp Ctr Hosp, Dept Radiol, Beijing, Peoples R China
7.Chinese Acad Med Sci & Peking Union Med Coll, Beijing, Peoples R China
8.Chinese Acad Sci, Brainnetome Ctr, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Tao,Xu, Yicheng,Li, Deying,et al. Network localization of transient global amnesia beyond the hippocampus[J]. NEUROLOGICAL SCIENCES,2022:9.
APA Wang, Tao.,Xu, Yicheng.,Li, Deying.,Tu, Wenjun.,Li, Yanan.,...&Yu, Shengyuan.(2022).Network localization of transient global amnesia beyond the hippocampus.NEUROLOGICAL SCIENCES,9.
MLA Wang, Tao,et al."Network localization of transient global amnesia beyond the hippocampus".NEUROLOGICAL SCIENCES (2022):9.

入库方式： OAI收割

来源：自动化研究所

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