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Biphasic flow dynamics and polarized mass transportation in branched hepatic sinusoids

文献类型：期刊论文

作者Hao, Yinjing3; Lu, Shouqin1,2; Li, Wang1,2; Long, Mian1,2; Cui, Yuhong3; Long M(龙勉); Lv SQ(吕守芹); Li W(李旺)
刊名BIOMICROFLUIDICS
出版日期2022-09-01
卷号16期号:5页码:12
DOI10.1063/5.0100911
通讯作者Long, Mian(mlong@imech.ac.cn) ; Cui, Yuhong(yhcui@tju.edu.cn)
英文摘要In fatty liver diseases, such as liver fibrosis and liver cirrhosis, blood flow in hepatic sinusoids, an elementary building block of the liver lobule, tends to bypass through collateral vessels inside sinusoids and presents distinct sinusoidal flows compared to normal physiological flows. It remains unclear in those flow characteristics in branched sinusoids and the correlation of pathological flows with liver lesions, mainly due to the difficulty of direct hemodynamics measurements in the sinusoids. Here, we developed a dual-branched theoretical model of hepatic sinusoidal flow to elucidate the relevant flow dynamics and mass transport. Numerical simulations, based on the lattice Boltzmann method, indicated that the flow velocity distribution in hepatic sinusoids is mainly dominated by endothelium permeability and presents a non-monotonic variation with the permeability at the fusion segment of these branched sinusoids. Flow-induced shear stress on the endothelium at the side of the Disse space exhibited a biphasic pattern, yielding a low shear stress region at the junctional site. Meanwhile, a highly polarized distribution of lipoproteins concentration was also presented at the low shear stress region, indicating a localized accumulation of typical hepatic serum proteins. Thus, this work provides the basic understanding of blood flow features and mass transport regulations in branched hepatic sinusoids. Published under an exclusive license by AIP Publishing.
WOS关键词BLOOD-FLOW ; LIPID-METABOLISM
资助项目National Natural Science Foundation of China (NNSFC) ; Frontier Science Key Project of Chinese Science Academy ; Tianjin Natural Science Foundation ; [11972252] ; [QYZDJ-SSW-JSC018] ; [17JCYBJC29300]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics ; Science & Technology - Other Topics ; Physics
语种英语
WOS记录号WOS:000876633500002
资助机构National Natural Science Foundation of China (NNSFC) ; Frontier Science Key Project of Chinese Science Academy ; Tianjin Natural Science Foundation
源URL[http://dspace.imech.ac.cn/handle/311007/90672]  
专题力学研究所_国家微重力实验室
通讯作者Long, Mian; Cui, Yuhong
作者单位1.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Natl Micrograv Lab, Beijing Key Lab Engn Construct & Mechanobiol, Ctr Biomech & Bioengn,Key Lab Micrograv,Inst Mech, Beijing, Peoples R China
3.Tianjin Univ, Dept Mech, Tianjin 300072, Peoples R China
推荐引用方式
GB/T 7714		 Hao, Yinjing,Lu, Shouqin,Li, Wang,et al. Biphasic flow dynamics and polarized mass transportation in branched hepatic sinusoids[J]. BIOMICROFLUIDICS,2022,16(5):12.
APA Hao, Yinjing.,Lu, Shouqin.,Li, Wang.,Long, Mian.,Cui, Yuhong.,...&李旺.(2022).Biphasic flow dynamics and polarized mass transportation in branched hepatic sinusoids.BIOMICROFLUIDICS,16(5),12.
MLA Hao, Yinjing,et al."Biphasic flow dynamics and polarized mass transportation in branched hepatic sinusoids".BIOMICROFLUIDICS 16.5(2022):12.

入库方式： OAI收割

来源：力学研究所

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