Megastigmane sesquiterpenoids from Saussurea medusa and their anti-inflammatory activities
文献类型：期刊论文
| 作者 | Cao, JY; Dong, Q; Wang, ZY; Zhao, Y; Ren, Y; Mei, LJ; Tao, YD; Yu, RT
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| 刊名 | NATURAL PRODUCT RESEARCH
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| 出版日期 | 2022 |
| 英文摘要 | Objectives: An ethanol extract of the whole plants of Saussurea medusa had been investigated to find novel anti-inflammatory sesquiterpenoids. Methods: Extensive spectroscopic data and chemical methods were applied to elucidate the structures of the compounds. Results: One new megastigmane sesquiterpenoid (1), along with 11 known analogues (2-12), were obtained from S. medusa. All isolates, except compounds 3 and 6, were mentioned from the studied plant for the first time. Compounds 1, 2, 4, 5, 7, 8 and 12 were firstly isolated from the genus Saussurea. Compounds 2, 9 and 10 were found to inhibit the lipopolysaccharide (LPS)-induced release of NO by RAW264.7 cells with IC50 values ranging from 21.1 +/- 1.7 to 46.7 +/- 1.9 mu M. Furthermore, iNOS expression experiment was performed to examine the interactions between the active compounds and the iNOS enzyme. |
| 源URL | [http://210.75.249.4/handle/363003/61053]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Cao, JY,Dong, Q,Wang, ZY,et al. Megastigmane sesquiterpenoids from Saussurea medusa and their anti-inflammatory activities[J]. NATURAL PRODUCT RESEARCH,2022. |
| APA | Cao, JY.,Dong, Q.,Wang, ZY.,Zhao, Y.,Ren, Y.,...&Yu, RT.(2022).Megastigmane sesquiterpenoids from Saussurea medusa and their anti-inflammatory activities.NATURAL PRODUCT RESEARCH. |
| MLA | Cao, JY,et al."Megastigmane sesquiterpenoids from Saussurea medusa and their anti-inflammatory activities".NATURAL PRODUCT RESEARCH (2022). |
入库方式： OAI收割
来源：西北高原生物研究所
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