Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity
文献类型：期刊论文
| 作者 | Ma, YH; Suo, XY; Li, XX; Zhu, TT; Li, J; Ji, TF; Liu, B |
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2022 |
| 卷号 | 203 |
| 英文摘要 | Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 mu M. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them. |
| 源URL | [http://210.75.249.4/handle/363003/61064]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Ma, YH,Suo, XY,Li, XX,et al. Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity[J]. PHYTOCHEMISTRY,2022,203. |
| APA | Ma, YH.,Suo, XY.,Li, XX.,Zhu, TT.,Li, J.,...&Liu, B.(2022).Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity.PHYTOCHEMISTRY,203. |
| MLA | Ma, YH,et al."Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity".PHYTOCHEMISTRY 203(2022). |
入库方式： OAI收割
来源：西北高原生物研究所
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