Assembled Fe3O4 nanoparticles on Zn-Al LDH nanosheets as a biocompatible drug delivery vehicle for pH-responsive drug release and enhanced anticancer activity
文献类型：期刊论文
| 作者 | Chai, JH; Ma, YY; Guo, TL; He, Y; Wang, GS; Si, FF; Geng, JH; Qi, XW; Chang, GQ; Ren, ZG |
| 刊名 | APPLIED CLAY SCIENCE
 |
| 出版日期 | 2022 |
| 卷号 | 228 |
| 英文摘要 | This article presented a facile two-step hydrothermal strategy to anchor the Fe3O4 nanoparticles on the surface of Zn-Al LDH nanosheets, and investigated systematically the potential application of the constructed Fe3O4/Zn-Al LDH nanocomposites in the biomedical field of controlled drug delivery. It was revealed that the formed Fe3O4/ Zn-Al LDH nanocomposites exhibited uniform mesopores, high surface area of 121.7 m2/g, good superparamagnetism and appropriate saturation magnetization of 40.7 emu/g. Due to these fascinating properties, this work explored the application of Fe3O4/Zn-Al LDH in the field of nanocarrier using the doxorubicin hydrochloride (DOX) as a model anticancer drug for the detailed investigations of drug loading capacity, controlled release behavior and cytotoxic effects under in vitro conditions. The Fe3O4/Zn-Al LDH showed a good drug storage capacity and a pH-responsive drug release profile. After loading the anti-cancer drugs, the DOX-loaded Fe3O4/Zn-Al LDH exhibited enhanced therapeutic effect on human hepatocellular carcinoma cells (HepG2), demonstrating that the fabricated Fe3O4/Zn-Al LDH nanocomposites have a great potential in cancer therapy. |
| 源URL | [http://210.75.249.4/handle/363003/61085]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Chai, JH,Ma, YY,Guo, TL,et al. Assembled Fe3O4 nanoparticles on Zn-Al LDH nanosheets as a biocompatible drug delivery vehicle for pH-responsive drug release and enhanced anticancer activity[J]. APPLIED CLAY SCIENCE,2022,228. |
| APA | Chai, JH.,Ma, YY.,Guo, TL.,He, Y.,Wang, GS.,...&Li, D.(2022).Assembled Fe3O4 nanoparticles on Zn-Al LDH nanosheets as a biocompatible drug delivery vehicle for pH-responsive drug release and enhanced anticancer activity.APPLIED CLAY SCIENCE,228. |
| MLA | Chai, JH,et al."Assembled Fe3O4 nanoparticles on Zn-Al LDH nanosheets as a biocompatible drug delivery vehicle for pH-responsive drug release and enhanced anticancer activity".APPLIED CLAY SCIENCE 228(2022). |
入库方式： OAI收割
来源：西北高原生物研究所
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