Insights Into miRNA-mRNA Regulatory Mechanisms of Cold Adaptation in Gymnocypris eckloni: Ubiquitin-Mediated Proteolysis Is Pivotal for Adaptive Energy Metabolism
文献类型：期刊论文
| 作者 | Nie, MM; Ni, WL; Wang, LH; Gao, Q; Liu, D; Tian, F ; Wang, ZJ; Zhang, CF; Qi, DL
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| 刊名 | FRONTIERS IN GENETICS
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| 出版日期 | 2022 |
| 卷号 | 13 |
| 英文摘要 | This study aimed to understand cold stress adaptations mechanism in fish. Thus, the transcriptional response to cold conditions in Gymnocypris eckloni was evaluated using RNA-seq and microRNA (miRNA)-seq analyses. Low-temperature (LT) group G. eckloni was cultivated outdoors in waters cooled to 2-4 degrees C for 3 weeks, while individuals in the control temperature (CT) group were exposed to 14-16 degrees C. Significantly different responses were observed in both mRNA and miRNA expression profiles, with more mRNAs (1,833 and 1,869 mRNAs were up- and downregulated, respectively) and fewer miRNAs (15 and 6 were up- and downregulated, respectively) observed in the LT group individuals relative to the CT group individuals. A miRNA-mRNA network involved in the regulation of G. eckloni responses to cold stress was constructed; this network included ubiquitin-mediated proteolysis, protein processing, and oxidative phosphorylation. These results provided new insights into mechanisms of cold tolerance by fish, including decreased metabolic activity in addition to proteolysis. |
| 源URL | [http://210.75.249.4/handle/363003/61149]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Nie, MM,Ni, WL,Wang, LH,et al. Insights Into miRNA-mRNA Regulatory Mechanisms of Cold Adaptation in Gymnocypris eckloni: Ubiquitin-Mediated Proteolysis Is Pivotal for Adaptive Energy Metabolism[J]. FRONTIERS IN GENETICS,2022,13. |
| APA | Nie, MM.,Ni, WL.,Wang, LH.,Gao, Q.,Liu, D.,...&Qi, DL.(2022).Insights Into miRNA-mRNA Regulatory Mechanisms of Cold Adaptation in Gymnocypris eckloni: Ubiquitin-Mediated Proteolysis Is Pivotal for Adaptive Energy Metabolism.FRONTIERS IN GENETICS,13. |
| MLA | Nie, MM,et al."Insights Into miRNA-mRNA Regulatory Mechanisms of Cold Adaptation in Gymnocypris eckloni: Ubiquitin-Mediated Proteolysis Is Pivotal for Adaptive Energy Metabolism".FRONTIERS IN GENETICS 13(2022). |
入库方式： OAI收割
来源：西北高原生物研究所
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