Specific ablation of Hippo signalling component Yap1 in retinal progenitors and Muller cells results in late onset retinal degeneration
文献类型：期刊论文
| 作者 | Yang, YM; Jiang, XY; Li, X ; Sun, KX; Zhu, XJ; Zhou, B
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| 刊名 | JOURNAL OF CELLULAR PHYSIOLOGY
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| 出版日期 | 2022 |
| 卷号 | 237期号:6页码:2673 |
| 英文摘要 | Yes-associated protein (YAP) is a major component of the Hippo pathway involved in development, growth, repair and homeostasis. Nonsense YAP1 mutations in humans result in autosomal dominant coloboma. Here, we generated a conditional knockout mouse model in which Yap1 was specifically deleted in embryonic retinal progenitor cells (RPCs) and in mature Muller cells using a Chx10-Cre driver. Our data demonstrated that the conditional ablation of Yap1 in embryonic RPCs does not prevent normal retinal development and caused no gross changes in retinal structure during embryonic and early postnatal life. Nevertheless, Yap1 deficient in retinal Muller cells in adult mice leads to impaired visual responses and extensive late-onset retinal degeneration, characterized by reduced cell number in all retinal layers. Immunofluorescence data further revealed the degeneration and death of rod and cone photoreceptors, bipolar cells, horizontal cells, amacrine cells and ganglion cells to varying degrees in aged knockout mice. Moreover, alteration of glial homeostasis and reactive gliosis were also observed. Finally, cell proliferation and TUNEL assay revealed that the broad retinal degeneration is mainly caused by enhanced apoptosis in late period. Together, this work uncovers that YAP is essential for the normal vision and retinal maintenance, highlighting the crucial role of YAP in retinal function and homeostasis. |
| 源URL | [http://210.75.249.4/handle/363003/61219]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Yang, YM,Jiang, XY,Li, X,et al. Specific ablation of Hippo signalling component Yap1 in retinal progenitors and Muller cells results in late onset retinal degeneration[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2022,237(6):2673. |
| APA | Yang, YM,Jiang, XY,Li, X,Sun, KX,Zhu, XJ,&Zhou, B.(2022).Specific ablation of Hippo signalling component Yap1 in retinal progenitors and Muller cells results in late onset retinal degeneration.JOURNAL OF CELLULAR PHYSIOLOGY,237(6),2673. |
| MLA | Yang, YM,et al."Specific ablation of Hippo signalling component Yap1 in retinal progenitors and Muller cells results in late onset retinal degeneration".JOURNAL OF CELLULAR PHYSIOLOGY 237.6(2022):2673. |
入库方式： OAI收割
来源：西北高原生物研究所
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