Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS
文献类型：期刊论文
| 作者 | Jia, WJ; Bi, QM; Jiang, SR; Tao, JH; Liu, LY; Yue, HL; Zhao, XH |
| 刊名 | FOOD & FUNCTION
 |
| 出版日期 | 2022 |
| 卷号 | 13期号:5页码:2456 |
| 英文摘要 | Codonopsis pilosula (Franch.) Nannf. (CPN), mainly planted in the northwest region, is a traditional Chinese medicine/good health food for nourishing qi and promoting blood circulation. This study firstly evaluated the inhibitory effects of the CPN extraction (CPNE) on alpha-glucosidase in vitro and in vivo, and tentatively confirmed its chemical ingredients by employing UHPLC-Triple-TOF-MS/MS. The CPNE had strong inhibitory activities against mammalian alpha-glucosidase (sucrase and maltase) and yeast alpha-glycosidase with semi-inhibitory concentrations (IC50) of 0.241 mg mL(-1), 0.326 mg mL(-1) and 1.167 mg mL(-1), respectively. In addition, the CPNE could significantly decrease the postprandial blood glucose (PBG) levels in the sucrose/maltose/starch tolerance assays of diabetic mice. Furthermore, a total of 29 compounds, including 3 alkaloids, 13 phenolic acids, 8 alcohol glycosides and 5 alkynosides, were assigned based on comparison with the standards and references, as well as the analysis of main fragments. These results demonstrated that CPN could be used as an adjuvant therapy or dietary supplements to effectively control the occurrence and development of diabetes. |
| 源URL | [http://210.75.249.4/handle/363003/61289]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Jia, WJ,Bi, QM,Jiang, SR,et al. Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS[J]. FOOD & FUNCTION,2022,13(5):2456. |
| APA | Jia, WJ.,Bi, QM.,Jiang, SR.,Tao, JH.,Liu, LY.,...&Zhao, XH.(2022).Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS.FOOD & FUNCTION,13(5),2456. |
| MLA | Jia, WJ,et al."Hypoglycemic activity of Codonopsis pilosula (Franch.) Nannf. in vitro and in vivo and its chemical composition identification by UPLC-Triple-TOF-MS/MS".FOOD & FUNCTION 13.5(2022):2456. |
入库方式： OAI收割
来源：西北高原生物研究所
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