Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry
文献类型：期刊论文
| 作者 | Qiao Xiao-Qiang1,2,3; Wang Rui1,2; Zhang Li-Hua3; Yang Geng-Liang1,2; Zhang Yu-Kui3 |
| 刊名 | chinese journal of analytical chemistry
 |
| 出版日期 | 2012-07-01 |
| 卷号 | 40期号:7页码:1123-1129 |
| 关键词 | Chemical derivatization High sensitive detection Mass spectrometry Peptide Review |
| 产权排序 | 2,1 |
| 通讯作者 | 乔晓强 |
| 英文摘要 | shotgun based strategy is a widely used method in proteome research. however, due to the high complexity and wide dynamic range, the detection sensitivity of peptides, especially for those with low abundance and low ionization efficiency, still can hardly meet the requirements. chemical derivatization has been proved to be one of the most promising methods. herein, the recent progress in the development of derivatization reagents targeting for the peptides as well as those with post-translational modifications, and its applications in high sensitive analysis in mass spectrometry are reviewed. furthermore, the future research directions and the potential application in proteome research are discussed. |
| WOS标题词 | science & technology ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | assisted-laser-desorption/ionization ; maldi-qit-tofmsn ; electrospray-ionization ; structural determination ; signal enhancement ; tryptic peptides ; ms/ms analysis ; amino-groups ; matrix ; oligosaccharides |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000308253300005 |
| 公开日期 | 2013-10-11 |
| 源URL | [http://159.226.238.44/handle/321008/117804]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Hebei Univ, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding 071002, Peoples R China 2.Hebei Univ, Coll Pharmaceut Sci, Baoding 071002, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiao Xiao-Qiang,Wang Rui,Zhang Li-Hua,et al. Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry[J]. chinese journal of analytical chemistry,2012,40(7):1123-1129. |
| APA | Qiao Xiao-Qiang,Wang Rui,Zhang Li-Hua,Yang Geng-Liang,&Zhang Yu-Kui.(2012).Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry.chinese journal of analytical chemistry,40(7),1123-1129. |
| MLA | Qiao Xiao-Qiang,et al."Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry".chinese journal of analytical chemistry 40.7(2012):1123-1129. |
入库方式： OAI收割
来源：大连化学物理研究所
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