Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices
文献类型：期刊论文
| 作者 | Ma, Huipeng; Zhang, Min; Qin, Jianhua |
| 刊名 | integrative biology
 |
| 出版日期 | 2012 |
| 卷号 | 4期号:5页码:522-530 |
| 产权排序 | 1,1 |
| 通讯作者 | 秦建华 |
| 英文摘要 | mesenchymal stem cells (mscs) are the progenitors of stromal cells, which have been found to interact with cancer cells and represent an important target for cancer therapies. salivary gland cancer is an aggressive malignant epithelial tumor and can easily disseminate to distant sites in vivo. in this work, we probed the role of mscs in salivary gland cancer in an in vivo like tumor microenvironment by using a series of functional microfluidic devices for 2d and 3d assays. the results demonstrated that mscs could be recruited by salivary gland cancer cells (acc-m) and this effect was potentially mediated by tgf-beta secreted by cancer cells. in addition, mscs exhibited the ability to squeeze into acc-m spheroids by dispersing the cell-cell connection and reducing the expression of e-cadherin in cancer cells. in particular, mscs exhibited the ability to enhance the invasion of salivary cancer under a chemokine cxcl12 gradient, indicating the involvement of a cxcl12-cxcr4 pathway and the tumor-promoting properties of mscs in cancer progression. this study recreated an in vivo-like tumor microenvironment by constructing a series of functional microdevices and explored the role of mscs in acc invasion for the first time. it provides a unique platform to open up new options to target stromal cells for cancer therapy and also analyzed the potential risk of using mscs as drug delivery carriers for therapeutic purposes in carcinoma treatment. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | cell biology |
| 研究领域[WOS] | cell biology |
| 关键词[WOS] | adenoid cystic carcinoma ; marrow stromal cells ; tumor-cells ; fibroblasts ; cxcr4 ; metastasis ; growth ; lung ; therapies ; melanoma |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000303321100007 |
| 公开日期 | 2013-10-11 |
| 源URL | [http://159.226.238.44/handle/321008/117875]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Beijing 100864, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Huipeng,Zhang, Min,Qin, Jianhua. Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices[J]. integrative biology,2012,4(5):522-530. |
| APA | Ma, Huipeng,Zhang, Min,&Qin, Jianhua.(2012).Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices.integrative biology,4(5),522-530. |
| MLA | Ma, Huipeng,et al."Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices".integrative biology 4.5(2012):522-530. |
入库方式： OAI收割
来源：大连化学物理研究所
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