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Altered neural mechanism of social reward anticipation in individuals with schizophrenia and social anhedonia

文献类型：期刊论文

作者Zhang, Yi-jing3,4; Hu, Hui-xin3,4; Wang, Ling-ling3,4; Wang, Xuan3,4; Wang, Yi3,4; Huang, Jia3,4; Wang, Ya3,4; Lui, Simon S. Y.2; Hui, Li1; Chan, Raymond C. K.3,4
刊名EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
出版日期2022-10-28
页码11
ISSN号0940-1334
关键词Social reward anticipation Social brain network Social network Social functioning Schizophrenia Social anhedonia
DOI10.1007/s00406-022-01505-6
通讯作者Chan, Raymond C. K.(rckchan@psych.ac.cn)
英文摘要Altered social reward anticipation could be found in schizophrenia (SCZ) patients and individuals with high levels of social anhedonia (SA). However, few research investigated the putative neural processing for altered social reward anticipation in these populations on the SCZ spectrum. This study aimed to examine the underlying neural mechanisms of social reward anticipation in these populations. Twenty-three SCZ patients and 17 healthy controls (HC), 37 SA individuals and 50 respective HCs completed the Social Incentive Delay (SID) imaging task while they were undertaking MRI brain scans. We used the group contrast to examine the alterations of BOLD activation and functional connectivity (FC, psychophysiological interactions analysis). We then characterized the beta-series social brain network (SBN) based on the meta-analysis results from NeuroSynth and examined their prediction effects on real-life social network (SN) characteristics using the partial least squared regression analysis. The results showed that SCZ patients exhibited hypo-activation of the left medial frontal gyrus and the negative FCs with the left parietal regions, while individuals with SA showed the hyper-activation of the left middle frontal gyrus when anticipating social reward. For the beta-series SBNs, SCZ patients had strengthened cerebellum-temporal FCs, while SA individuals had strengthened left frontal regions FCs. However, such FCs of the SBN failed to predict the real-life SN characteristics. These preliminary findings suggested that SCZ patients and SA individuals appear to exhibit altered neural processing for social reward anticipation, and such neural activities showed a weakened association with real-life SN characteristics.
收录类别SCI
WOS关键词BRAIN ; MOTIVATION ; NETWORK ; CONNECTIONS ; MONETARY ; PEOPLE ; AUTISM ; SCALE
资助项目Jiangsu Provincial Key Research and Development Programme[BE2020661] ; CAS Key Laboratory of Mental Health, Institute of Psychology, the Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX3415CX] ; Phillip K.H. Wong Foundation ; National Science Foundation China[31871114]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
出版者SPRINGER HEIDELBERG
WOS记录号WOS:000876654800002
资助机构Jiangsu Provincial Key Research and Development Programme ; CAS Key Laboratory of Mental Health, Institute of Psychology, the Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; Phillip K.H. Wong Foundation ; National Science Foundation China
源URL[http://ir.psych.ac.cn/handle/311026/43863]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Chan, Raymond C. K.
作者单位1.Soochow Univ, Med Coll, Affiliated Guangji Hosp, Suzhou, Jiangsu, Peoples R China
2.Univ Hong Kong, Sch Clin Med, Dept Psychiat, Hong Kong, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yi-jing,Hu, Hui-xin,Wang, Ling-ling,et al. Altered neural mechanism of social reward anticipation in individuals with schizophrenia and social anhedonia[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2022:11.
APA Zhang, Yi-jing.,Hu, Hui-xin.,Wang, Ling-ling.,Wang, Xuan.,Wang, Yi.,...&Chan, Raymond C. K..(2022).Altered neural mechanism of social reward anticipation in individuals with schizophrenia and social anhedonia.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,11.
MLA Zhang, Yi-jing,et al."Altered neural mechanism of social reward anticipation in individuals with schizophrenia and social anhedonia".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2022):11.

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来源：心理研究所

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