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Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction

文献类型：期刊论文

作者Dai, Zhonghua2,3; Liu, Ying2,3; Nie, Lina2,3; Chen, Weiqi1,2,3; Xu, Xing2,3; Li, Yonghui1,2,3; Zhang, Jianjun2,3; Shen, Fang2,3; Sui, Nan2,3; Liang, Jing1,2,3
刊名NEUROPSYCHOPHARMACOLOGY
出版日期2022-10-27
页码14
ISSN号0893-133X
DOI10.1038/s41386-022-01477-0
通讯作者Liang, Jing(liangj@psych.ac.cn)
英文摘要Extinction training during the reconsolidation window following memory recall is an effective behavioral pattern for promoting the extinction of pathological memory. However, promoted extinction by recall-extinction procedure has not been universally replicated in different studies. One potential reason for this may relate to whether initially acquired memory is successfully activated. Thus, the methods for inducing the memory into an active or plastic condition may contribute to promoting its extinction. The aim of this study is to find and demonstrate a manipulatable neural circuit that engages in the memory recall process and where its activation improves the extinction process through recall-extinction procedure. Here, naloxone-precipitated conditioned place aversion (CPA) in morphine-dependent mice was mainly used as a pathological memory model. We found that the locus coeruleus (LC)-dentate gyrus (DG) circuit was necessary for CPA memory recall and that artificial activation of LC inputs to the DG just prior to initiating a recall-extinction procedure significantly promoted extinction learning. We also found that activating this circuit caused an increase in the ensemble size of DG engram cells activated during the extinction, which was confirmed by a cFos targeted strategy to label cells combined with immunohistochemical and in vivo calcium imaging techniques. Collectively, our data uncover that the recall experience is important for updating the memory during the reconsolidation window; they also suggest a promising neural circuit or target based on the recall-extinction procedure for weakening pathological aversion memory, such as opioid withdrawal memory and fear memory.
收录类别SCI
WOS关键词POST-RETRIEVAL EXTINCTION ; CONDITIONED PLACE AVERSION ; PATTERN SEPARATION ; FEAR EXTINCTION ; MEMORY ; RECONSOLIDATION ; NEURONS ; NOREPINEPHRINE ; NORADRENALINE ; CONSOLIDATION
资助项目National Natural Science Foundation of China[32071028] ; Natural Science Foundation of Beijing Municipality[5202023] ; CAS-VPST Silk Road Science Fund 2021[GJHZ202129]
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
语种英语
出版者SPRINGERNATURE
WOS记录号WOS:000874397600002
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality ; CAS-VPST Silk Road Science Fund 2021
源URL[http://ir.psych.ac.cn/handle/311026/43873]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Liang, Jing
作者单位1.Univ Chinese Acad Sci, Sino Danish Ctr Educ & Res, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Dai, Zhonghua,Liu, Ying,Nie, Lina,et al. Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction[J]. NEUROPSYCHOPHARMACOLOGY,2022:14.
APA Dai, Zhonghua.,Liu, Ying.,Nie, Lina.,Chen, Weiqi.,Xu, Xing.,...&Liang, Jing.(2022).Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction.NEUROPSYCHOPHARMACOLOGY,14.
MLA Dai, Zhonghua,et al."Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction".NEUROPSYCHOPHARMACOLOGY (2022):14.

入库方式： OAI收割

来源：心理研究所

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