Targeting NMDA Receptors in Emotional Disorders: Their Role in Neuroprotection
文献类型：期刊论文
| 作者 | Wang, Siqi2,3; Bian, Lihua1,2; Yin, Yi2,3; Guo, Jianyou2,3
|
| 刊名 | BRAIN SCIENCES
 |
| 出版日期 | 2022-10-01 |
| 卷号 | 12期号:10页码:17 |
| 关键词 | NMDAR depression anxiety neuroprotection |
| DOI | 10.3390/brainsci12101329 |
| 通讯作者 | Guo, Jianyou(guojy@psych.ac.cn) |
| 英文摘要 | Excitatory glutamatergic neurotransmission mediated through N-methyl-D-Aspartate (NMDA) receptors (NMDARs) is essential for synaptic plasticity and neuronal survival. While under pathological states, abnormal NMDAR activation is involved in the occurrence and development of psychiatric disorders, which suggests a directional modulation of NMDAR activity that contributes to the remission and treatment of psychiatric disorders. This review thus focuses on the involvement of NMDARs in the pathophysiological processes of psychiatric mood disorders and analyzes the neuroprotective mechanisms of NMDARs. Firstly, we introduce NMDAR-mediated neural signaling pathways in brain function and mood regulation as well as the pathophysiological mechanisms of NMDARs in emotion-related mental disorders such as anxiety and depression. Then, we provide an in-depth summary of current NMDAR modulators that have the potential to be developed into clinical drugs and their pharmacological research achievements in the treatment of anxiety and depression. Based on these findings, drug-targeting for NMDARs might open up novel territory for the development of therapeutic agents for refractory anxiety and depression. |
| 收录类别 | SCI |
| WOS关键词 | D-ASPARTATE RECEPTOR ; PROOF-OF-CONCEPT ; TREATMENT-RESISTANT DEPRESSION ; FUNCTIONAL PARTIAL AGONIST ; LONG-TERM POTENTIATION ; GLUTAMATE RECEPTORS ; MAJOR DEPRESSION ; RANDOMIZED-TRIAL ; CELL-DEATH ; SYNAPTIC PLASTICITY |
| 资助项目 | National Natural Science Foundation of China[82073971] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX4115CX] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:000875956300001 |
| 资助机构 | National Natural Science Foundation of China ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences |
| 源URL | [http://ir.psych.ac.cn/handle/311026/43885]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Guo, Jianyou |
| 作者单位 | 1.Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325001, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Siqi,Bian, Lihua,Yin, Yi,et al. Targeting NMDA Receptors in Emotional Disorders: Their Role in Neuroprotection[J]. BRAIN SCIENCES,2022,12(10):17. |
| APA | Wang, Siqi,Bian, Lihua,Yin, Yi,&Guo, Jianyou.(2022).Targeting NMDA Receptors in Emotional Disorders: Their Role in Neuroprotection.BRAIN SCIENCES,12(10),17. |
| MLA | Wang, Siqi,et al."Targeting NMDA Receptors in Emotional Disorders: Their Role in Neuroprotection".BRAIN SCIENCES 12.10(2022):17. |
入库方式： OAI收割
来源：心理研究所
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