Characterizations of Alpha-Cellulose and Microcrystalline Cellulose Isolated from Cocoa Pod Husk as a Potential Pharmaceutical Excipient
文献类型：期刊论文
| 作者 | Adeleye, Olutayo A.10,11; Bamiro, Oluyemisi A.1; Albalawi, Doha A.2; Alotaibi, Amenah S.3; Iqbal, Haroon4; Sanyaolu, Saheed1; Femi-Oyewo, Mbang N.11; Sodeinde, Kehinde O.5; Yahaya, Zwanden S.6; Thiripuranathar, Gobika7 |
| 刊名 | MATERIALS
 |
| 出版日期 | 2022-09-01 |
| 卷号 | 15 |
| 关键词 | alpha cellulose microcrystalline cellulose cocoa pod husk direct compression metronidazole tablet |
| DOI | 10.3390/ma15175992 |
| 通讯作者 | Adeleye, Olutayo A.(olutayo.adeleye@fuoye.edu.ng) ; Menaa, Farid(menaateam@gmail.com) |
| 英文摘要 | Cellulose is a non-toxic, bio-degradable, and renewable biopolymer which is abundantly available in nature. The most common source of commercial microcrystalline cellulose is fibrous wood pulp. Cellulose and its derivatives have found wide commercial applications in the pharmaceutical, cosmetic, food, paper, textile, and engineering industries. This study aims to isolate and characterize cellulose forms from cocoa pod husk (CPH) and to assess its mechanical and disintegration properties as a direct compression excipient in metronidazole tablets. Two isolated cellulose types (i.e., cocoa alpha-cellulose (CAC) and cocoa microcrystalline cellulose (C-MCC)) were compared with avicel (AV). CAC and C-MCC were characterized for their physicochemical properties using Scanning Electron Microscopy (SEM), FTIR spectroscopy, Differential Scanning Calorimetry (DSC), and X-Ray Powder Diffraction (XRD). Metronidazole tablets were produced by direct compression with cellulose. The mechanical and disintegration properties of the tablets were evaluated. CAC and C-MCC yield was 42.3% w/w and 38.25% w/w, respectively. Particle diameters were significantly different with CAC (282.22 mu m) > C-MCC (161.32 mu m) > AV (72.51 mu m). CAC and C-MCC had a better flow than AV. SEM revealed the fibrous nature of the cellulose. FTIR and XRD analysis confirmed the presence of cellulose with crystallinity index of 69.26%, 43.83%, and 26.32% for AV, C-MCC, and CAC, respectively. C-MCC and AV are more crystalline and thermally stable at high temperatures compared to CAC. The mechanical and disintegration properties of C-MCC and AV tablets complied with pharmacopeia specifications. Taken together, C-MCC isolated from CPH displayed some fundamental characteristics suitable for use as a pharmaceutical excipient and displayed better properties compared to that of AV. |
| WOS关键词 | NANOCRYSTALS ; FIBERS ; CRYSTALLINITY ; EXTRACTION ; BIOMASS ; ENERGY ; FLOW |
| WOS研究方向 | Chemistry ; Materials Science ; Metallurgy & Metallurgical Engineering ; Physics |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:000851795600001 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/128822]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Adeleye, Olutayo A.; Menaa, Farid |
| 作者单位 | 1.Olabisi Onabanjo Univ, Dept Pharmaceut & Pharmaceut Technol, Ago Iwoye 120107, Ogun State, Nigeria 2.Univ Tabuk, Fac Sci, Dept Biol, Tabuk 71491, Saudi Arabia 3.Univ Tabuk, Fac Sci, Dept Biol, Genom & Biotechnol Unit, Tabuk 71491, Saudi Arabia 4.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp,Canc Hosp, Hangzhou 310022, Peoples R China 5.Fed Univ Oye Ekiti, Dept Ind Chem, Oye Ekiti 3600001, Ekiti State, Nigeria 6.Kaduna State Univ, Dept Pharmaceut & Ind Pharm, Kabala Coastain 800283, Kaduna State, Nigeria 7.Coll Chem Sci, Inst Chem Ceylon, Rajagiriya 10107, Sri Lanka 8.Calif Innovat Corp, San Diego, CA 92037 USA 9.Fluorotron Inc, Dept Pharmaceut & Nanomed, San Diego, CA 92037 USA 10.Fed Univ Oye Ekiti, Dept Pharmaceut & Pharmaceut Technol, Oye Ekiti 3600001, Ekiti State, Nigeria |
| 推荐引用方式 GB/T 7714 | Adeleye, Olutayo A.,Bamiro, Oluyemisi A.,Albalawi, Doha A.,et al. Characterizations of Alpha-Cellulose and Microcrystalline Cellulose Isolated from Cocoa Pod Husk as a Potential Pharmaceutical Excipient[J]. MATERIALS,2022,15. |
| APA | Adeleye, Olutayo A..,Bamiro, Oluyemisi A..,Albalawi, Doha A..,Alotaibi, Amenah S..,Iqbal, Haroon.,...&Menaa, Farid.(2022).Characterizations of Alpha-Cellulose and Microcrystalline Cellulose Isolated from Cocoa Pod Husk as a Potential Pharmaceutical Excipient.MATERIALS,15. |
| MLA | Adeleye, Olutayo A.,et al."Characterizations of Alpha-Cellulose and Microcrystalline Cellulose Isolated from Cocoa Pod Husk as a Potential Pharmaceutical Excipient".MATERIALS 15(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。