High expression of ceramide synthase 5 predicts a poor prognosis in gastric cancer
文献类型：期刊论文
| 作者 | Zhang, Shengjie1,2; Wang, Yi3 ; Yuan, Li1,2; Hu, Can1,2,3; Xu, Zhiyuan1,2; Cheng, Xiangdong1,2,4
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| 刊名 | TRANSLATIONAL CANCER RESEARCH
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| 出版日期 | 2022-08-17 |
| 关键词 | Gastric cancer ceramide synthase 5 (CerS5) prognosis The Cancer Genome Atlas (TCGA) Asian Cancer Research Group (ACRG) |
| ISSN号 | 2218-676X |
| DOI | 10.21037/tcr-22-1348 |
| 通讯作者 | Cheng, Xiangdong(chengxd@zjcc.org.cn) |
| 英文摘要 | Background: Gastric cancer is one of the most common malignant tumors worldwide. Ceramide synthase 5 (CerS5) is a member of the CerS family. Emerging evidence has shown that overexpressed CerS5 is correlated with the poor prognosis of cancer patients. However, the role of CerS5 in gastric cancer remains unclear. The aim of this study is to delineate the relevance of CerS5 levels to gastric cancer.Methods: The expression level of CerS5 was determined by immunohistochemistry, and the survival data of gastric cancer patients were obtained by regular follow-up. The gene expression profile of CerS5 and corresponding clinical features of gastric cancer patients from public databases were obtained from The Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG). The Chi-square test and Fisher's exact test were used to determine the correlation between CerS5 expression and clinicopathological characteristics of gastric cancer patients. Univariate and multivariate Cox regression analyses were used to determine the independent prognostic factors of patients with gastric cancer.Results: Immunohistochemistry (IHC) staining indicated that CerS5 is overexpressed in gastric cancer tissues and metastatic lymph nodes. The levels of CerS5 were correlated with tumor location and carbohydrate antigen 50 (CA50). Moreover, the increased CerS5 levels were significantly correlated with poor prognosis in gastric cancer patients from the ACRG and our institute, but not TCGA, suggesting that CerS5 is probably a prognosis marker of gastric cancer for the Asian population. Finally, univariate and multivariate analyses showed that high expression of CerS5 is an independent factor of poor prognosis for gastric cancer patients.Conclusions: CerS5 is universally overexpressed in gastric cancer tissues and is an independent factor of poor prognosis for gastric cancer patients. |
| WOS关键词 | SPHINGOLIPID METABOLISM ; APOPTOSIS ; SURVIVAL ; GROWTH ; CERS5 ; SERUM |
| 资助项目 | National Natural Science Foundation of China[81502603] ; Natural Science Foundation of Zhejiang Province[LGF18H160016] ; Medicine and Health Science Fund of Zhejiang Province[2022KY691] ; Key Laboratory of Prevention, Diagnosis, and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province[2022E10021] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000851113800001 |
| 出版者 | AME PUBLISHING COMPANY |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Zhejiang Province ; Medicine and Health Science Fund of Zhejiang Province ; Key Laboratory of Prevention, Diagnosis, and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/128857]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Cheng, Xiangdong |
| 作者单位 | 1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc IBMC, Chinese Acad Sci,Canc Hosp, Hangzhou, Peoples R China 2.Upper Gastrointestinal Canc Zhejiang Prov, Key Lab Prevent Diag & Therapy, Hangzhou, Peoples R China 3.Zhejiang Chinese Med Univ, Clin Med Coll 1, Hangzhou, Peoples R China 4.Zhejiang Canc Hosp, 1 East Banshan Rd, Hangzhou 310022, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Shengjie,Wang, Yi,Yuan, Li,et al. High expression of ceramide synthase 5 predicts a poor prognosis in gastric cancer[J]. TRANSLATIONAL CANCER RESEARCH,2022. |
| APA | Zhang, Shengjie,Wang, Yi,Yuan, Li,Hu, Can,Xu, Zhiyuan,&Cheng, Xiangdong.(2022).High expression of ceramide synthase 5 predicts a poor prognosis in gastric cancer.TRANSLATIONAL CANCER RESEARCH. |
| MLA | Zhang, Shengjie,et al."High expression of ceramide synthase 5 predicts a poor prognosis in gastric cancer".TRANSLATIONAL CANCER RESEARCH (2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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