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Evaluation of Rhesus Macaque Models for Cerebral Palsy

文献类型：期刊论文

作者Zhu, Yong1,4; Xiong, Yanan2,5; Zhang, Jin1; Tong, Haiyang1; Yang, Hongyi1; Zhu, Qingjun1; Xu, Xiaoyan5; Wu, De5; Tang, Jiulai5; Li, Jinhua3,4
刊名BRAIN SCIENCES
出版日期2022-09-01
卷号12
关键词cerebral palsy rhesus macaque animal model evaluation methodology
DOI10.3390/brainsci12091243
通讯作者Tang, Jiulai(tangjiulai8888@163.com) ; Li, Jinhua(jhli@ahu.edu.cn)
英文摘要Simple Summary Cerebral palsy (CP) is caused by a non-progressive injury that affects the central nervous system during early development. According to the World Health Organization, CP occurs in approximately 2-4 of 1000 newborns. Animal models, especially non-human primate models, have greatly assisted our understanding of CP, and have provided simulative objects for treatment. In this study, the rhesus macaque CP models were established by partial resection of the motor cortex and the intrathecal injection of bilirubin. We evaluated abnormal posture, motor dysfunction, gross and fine motor behavior, muscular tension of rhesus macaque CP models, and changes in the cerebral cortex and basal ganglia, the last of which were observed using magnetic resonance imaging. This model evaluation methodology may guide researchers through the model building process. The findings serve as a reference for establishing and assessing non-human primate CP models. Animal models play a central role in all areas of biomedical research. The similarities in anatomical structure and physiological characteristics shared by non-human primates (NHPs) and humans make NHPs ideal models with which to study human disorders, such as cerebral palsy (CP). However, the methodologies for systematically evaluating NHP models of CP have rarely been assessed, despite the long history of using NHP models to understand CP. Such models should be evaluated using multidisciplinary approaches prior to being used to research the diagnosis and treatment of CP. In this study, we evaluated rhesus macaque CP models established by partial resection of the motor cortex and intrathecal injection of bilirubin. Abnormal posture, motor dysfunction, gross and fine motor behavior, and muscular tension were evaluated, and changes in the cerebral cortex and basal ganglia were observed using 9.4 T magnetic resonance imaging. The results clearly demonstrated the utility of the established evaluation methodology for assessing CP models. This model evaluation methodology may guide researchers through the model building process.
WOS关键词BRAIN-DAMAGE ; ASPHYXIA ; MONKEY
资助项目National Natural Science Foundation of China[31971404] ; Anhui Provincial Natural Science Foundation[2008085MC105] ; Anhui Provincial Natural Science Research Project of Higher Education[KJ2020A0095] ; Research Foundation for Talented Scholars of Hefei Normal University[2020rcjj46]
WOS研究方向Neurosciences & Neurology
语种英语
出版者MDPI
WOS记录号WOS:000857677100001
资助机构National Natural Science Foundation of China ; Anhui Provincial Natural Science Foundation ; Anhui Provincial Natural Science Research Project of Higher Education ; Research Foundation for Talented Scholars of Hefei Normal University
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/128958]  
专题中国科学院合肥物质科学研究院
通讯作者Tang, Jiulai; Li, Jinhua
作者单位1.Chinese Acad Sci, High Magnet Field Lab, 350 Shushanhu Rd, Hefei 230031, Peoples R China
2.Tongji Univ, Dept Emergency, Tongji Hosp, 389 Xincun Rd, Shanghai 200065, Peoples R China
3.Anhui Univ, Int Collaborat Res Ctr Huangshan Biodivers & Tibe, Sch Resources & Environm Engn, 111 Jiulong Rd, Hefei 230601, Peoples R China
4.Hefei Normal Univ, Sch Life Sci, 1688 Lianhua Rd, Hefei 230601, Peoples R China
5.Anhui Med Univ, Pediat Neurol Rehabil Ctr, Affiliated Hosp 1, 218 Jixi Rd, Hefei 230022, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Yong,Xiong, Yanan,Zhang, Jin,et al. Evaluation of Rhesus Macaque Models for Cerebral Palsy[J]. BRAIN SCIENCES,2022,12.
APA Zhu, Yong.,Xiong, Yanan.,Zhang, Jin.,Tong, Haiyang.,Yang, Hongyi.,...&Li, Jinhua.(2022).Evaluation of Rhesus Macaque Models for Cerebral Palsy.BRAIN SCIENCES,12.
MLA Zhu, Yong,et al."Evaluation of Rhesus Macaque Models for Cerebral Palsy".BRAIN SCIENCES 12(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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