中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
Low Temperature Plasma Suppresses Lung Cancer Cells Growth via VEGF/VEGFR2/RAS/ERK Axis

文献类型：期刊论文

作者Zhou, Yuanyuan2; Zhang, Yan2; Bao, Jie2,3; Chen, Jinwu2,4; Song, Wencheng1,2,3
刊名MOLECULES
出版日期2022-09-01
卷号27
关键词low temperature plasma lung cancer cell ROS RNS cell death
DOI10.3390/molecules27185934
通讯作者Chen, Jinwu(yunliuqiye@163.com) ; Song, Wencheng(wencsong@cmpt.ac.cn)
英文摘要Low temperature plasma (LTP) is a promising cancer therapy in clinical practice. In this study, dielectric barrier discharge plasma with helium gas was used to generate LTP. Significant increases in extracellular and intracellular reactive species were found in lung cancer cells (CALU-1 and SPC-A1) after LTP treatments. Cells viability and apoptosis assays demonstrated that LTP inhibited cells viability and induced cells death, respectively. Moreover, Western blotting revealed that the growth of CALU-1 cells was suppressed by LTP via the VEGF/VEGFR2/RAS/ERK axis for the first time. The results showed that LTP-induced ROS and RNS could inhibit the growth of lung cancer cells via VEGF/VEGFR2/RAS/ERK axis. These findings advance our understanding of the inhibitory mechanism of LTP on lung cancer and will facilitate its clinical application.
WOS关键词PATHWAY ; INHIBITOR ; SURVIVAL ; VEGF ; RAF
资助项目National Natural Science Foundation of China[21876179] ; National Natural Science Foundation of China[22006001] ; China Postdoctoral Science Foundation[2020T130117ZX] ; China Postdoctoral Science Foundation[2020M671914] ; China Postdoctoral Science Foundation[2020B470]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者MDPI
WOS记录号WOS:000856760900001
资助机构National Natural Science Foundation of China ; China Postdoctoral Science Foundation
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/128968]  
专题中国科学院合肥物质科学研究院
通讯作者Chen, Jinwu; Song, Wencheng
作者单位1.Soochow Univ, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst & Sch Radiol & Interdisc, Suzhou 215123, Peoples R China
2.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China
3.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China
4.Hefei Normal Univ, Sch Life Sci, Hefei 230061, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Yuanyuan,Zhang, Yan,Bao, Jie,et al. Low Temperature Plasma Suppresses Lung Cancer Cells Growth via VEGF/VEGFR2/RAS/ERK Axis[J]. MOLECULES,2022,27.
APA Zhou, Yuanyuan,Zhang, Yan,Bao, Jie,Chen, Jinwu,&Song, Wencheng.(2022).Low Temperature Plasma Suppresses Lung Cancer Cells Growth via VEGF/VEGFR2/RAS/ERK Axis.MOLECULES,27.
MLA Zhou, Yuanyuan,et al."Low Temperature Plasma Suppresses Lung Cancer Cells Growth via VEGF/VEGFR2/RAS/ERK Axis".MOLECULES 27(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。